N'-[(S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-N-methyl-hydrazinecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: N'-[(S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-N-methyl-hydrazinecarboxylic acid tert-butyl ester
• CAS No.: 202813-48-7
• Molecular Formula: C₃₇H₃₇Cl₂N₃O₆
• Molecular Weight: 690.623
• Mol file: 202813-48-7.mol

Synonyms:N'-[(S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-N-methyl-hydrazinecarboxylic acid tert-butyl ester

Chemical Property of N'-[(S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-N-methyl-hydrazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[(S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-N-methyl-hydrazinecarboxylic acid tert-butyl ester

There total 1 articles about N'-[(S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-N-methyl-hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-methyl-1-tert-butoxycarbonylhydrazine (21075-83-2) + Fmoc-Tyr(2,6-Cl2Bzl)-OH (112402-12-7) → N'-[(S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-N-methyl-hydrazinecarboxylic acid tert-butyl ester (202813-48-7)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile;

DOI:10.1016/S0960-894X(97)10198-6

Reference yield:

N'-[(S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-N-methyl-hydrazinecarboxylic acid tert-butyl ester (202813-48-7) → C31H45N7O7

Guidance literature:

Multi-step reaction with 6 steps

1: TFA / CH₂Cl₂

2: 80 percent / DMAP

3: TFA / CH₂Cl₂

4: Et₃N

5: piperidine

6: H₂ / Pd

With piperidine; dmap; hydrogen; triethylamine; trifluoroacetic acid; palladium; In dichloromethane;

DOI:10.1016/S0960-894X(97)10198-6

Reference yield:

N'-[(S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-N-methyl-hydrazinecarboxylic acid tert-butyl ester (202813-48-7) → Tyr-Alaa-Glya-Phe-Leu

Guidance literature:

Multi-step reaction with 7 steps

1: TFA / CH₂Cl₂

2: 80 percent / DMAP

3: TFA / CH₂Cl₂

4: Et₃N

5: piperidine

6: H₂ / Pd

7: CH₂Cl₂

With piperidine; dmap; hydrogen; triethylamine; trifluoroacetic acid; palladium; In dichloromethane;

DOI:10.1016/S0960-894X(97)10198-6

upstream raw materials:

1-methyl-1-tert-butoxycarbonylhydrazine

Fmoc-Tyr(2,6-Cl₂Bzl)-OH

Downstream raw materials:

C₃₈H₃₉Cl₂N₅O₇

C₅₃H₅₉Cl₂N₇O₉