1-Boc-1-methylhydrazine

Base Information

• Chemical Name: 1-Boc-1-methylhydrazine
• CAS No.: 21075-83-2
• Molecular Formula: C6H14 N2 O2
• Molecular Weight: 146.189
• Hs Code.: 2928000090
• European Community (EC) Number: 629-342-4
• DSSTox Substance ID: DTXSID40395881
• Nikkaji Number: J1.225.606J
• Wikidata: Q72503650
• Mol file: 21075-83-2.mol

Synonyms:1-Boc-1-methylhydrazine;21075-83-2;tert-butyl N-amino-N-methylcarbamate;BOC-1-METHYLHYDRAZINE;tert-butyl 1-methylhydrazinecarboxylate;N-methyl(tert-butoxy)carbohydrazide;tert-Butyl N-amino-N-methyl-carbamate;2-Methylcarbazic acid tert-butyl ester;Hydrazinecarboxylic acid, 1-methyl-, 1,1-dimethylethyl ester;MFCD05669700;1-tert-Butoxycarbonyl-1-methylhydrazine;N-methylhydrazinecarboxylic acid tert-butyl ester;N-Boc-N-methylhydrazine;tert-Butyl 2-methylcarbazate;N-(tert-Butoxycarbonyl)-N-methylhydrazine;Boc-N(Me)-NH2;t-butyl 2-methylcarbazate;N-Boc-N-methyl-hydrazine;N'-Boc-N'-Methyl Hydrazine;SCHEMBL432112;1-Boc-1-methylhydrazine, 97%;DTXSID40395881;IHMQNZFRFVYNDS-UHFFFAOYSA-N;t-Butyl 1-methylhydrazinecarboxylate;1-t-butoxycarbonyl-1-methylhydrazine;AKOS005107577;n-tert-butoxycarbonyl-n-methylhydrazine;CS-W007496;MS-1772;N-methyl-N-tert-butoxycarbonylhydrazine;SB86049;AC-23821;SY017557;1-[(t-butyloxy)carbonyl]-1-methylhydrazine;B3998;FT-0687341;EN300-51900;(1,1-Dimethylethoxy)carbonyl-1-methylhydrazine;1,1-dimethylethyl 1-methylhydrazine carboxylate;1,1-Dimethylethyl 1-methylhydrazinecarboxylate;2-Methyl-2-propanyl 1-methylhydrazinecarboxylate;A815118;N-methyl-hydrazinecarboxylic acid tert-butyl ester;1-[(1,1-Dimethylethoxy)carbonyl]-1-methylhydrazine;J-504336;N-Methyl-hydrazine Carboxylic Acid Tert-Butyl Ester;1-methylhydrazinecarboxylic acid, 1,1 -dimethylethyl ester;1-Methylhydrazinecarboxylic acid, 1,1-dimethylethyl ester;Hydrazinecarboxylic acid,1-methyl-,1,1-dimethylethylester

Chemical Property of 1-Boc-1-methylhydrazine

Chemical Property:

• Refractive Index: n20/D 1.436
• Boiling Point: 186℃
• PKA: 3.28±0.10(Predicted)
• Flash Point: 71oC
• PSA: 55.56000
• Density: 0.985 g/mL at 25oC
• LogP: 1.42730
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 146.105527694
• Heavy Atom Count: 10
• Complexity: 128

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 1-Methylhydrazinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N(C)N
• Uses: tert-Butyl 1-Methylhydrazinecarboxylate is a reactant in the synthesis of the hydrazide of (2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane, the lead structure of the irreversible cathepsin C inhibitor.

Technology Process of 1-Boc-1-methylhydrazine

There total 14 articles about 1-Boc-1-methylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + methylhydrazine (60-34-4) → 1-methyl-1-tert-butoxycarbonylhydrazine (21075-83-2)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 0 - 20 ℃; for 3h;

DOI:10.1016/S0960-894X(03)00393-7

Reference yield: 82.0%

di-tert-butyl dicarbonate (24424-99-5) + methylhydrazine sulfuric acid (302-15-8) → 1-methyl-1-tert-butoxycarbonylhydrazine (21075-83-2)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 5 ℃; for 12h; pH=10;

Reference yield: 79.0%

di-tert-butyl dicarbonate (24424-99-5) → 1-methyl-1-tert-butoxycarbonylhydrazine (21075-83-2)

Guidance literature:

methylhydrazine sulfuric acid; With sodium hydrogencarbonate; In water; at 0 ℃; pH=11 - ~ 12;

di-tert-butyl dicarbonate; In tetrahydrofuran; water; at 20 ℃;

upstream raw materials:

S-Methyl-monothiokohlensaeure-tert.-butylester

methylhydrazine

1,1-dimethylethyl 2,4,5-trichlorophenyl carbonate

di-tert-butyl dicarbonate

Downstream raw materials:

4-Benzyl-1-(tert.-butoxycarbonyl)-1-methyl-thiosemicarbazid

N'-benzylidene-N-methylhydrazinecarboxylic acid tert-butyl ester

1-tert.-Butoxycarbonyl-1-methyl-4-phenyl-thiosemicarbazid

2-benzyl 1-tert-butyl 1-methylhydrazine-1,2-dicarboxylate