Phenyl-methanesulfinic acid (S)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl ester

Base Information

Chemical Name:Phenyl-methanesulfinic acid (S)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl ester
CAS No.:135790-18-0
Molecular Formula:C₂₂H₂₂O₃S
Molecular Weight:366.481
Hs Code.:

Synonyms:Phenyl-methanesulfinic acid (S)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl ester

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Chemical Property of Phenyl-methanesulfinic acid (S)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl ester

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Technology Process of Phenyl-methanesulfinic acid (S)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl ester

There total 2 articles about Phenyl-methanesulfinic acid (S)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 126577-49-9
(2R,5S)-trans-4,4-diphenyl-5-methyl-1,3,2-dioxathiolane 2-oxide

: 6921-34-2
benzylmagnesium chloride

: 135790-15-7
Phenyl-methanesulfinic acid (S)-2-hydroxy-1,1-diphenyl-propyl ester

: 135790-18-0
Phenyl-methanesulfinic acid (S)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl ester

Guidance literature:: In tetrahydrofuran; at -78 ℃; Yields of byproduct given;
DOI:10.1021/jo00021a008

Reference yield:

: 46755-94-6
(S)-1,1-diphenyl-1,2-propanediol

: 135790-18-0
Phenyl-methanesulfinic acid (S)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / SOCl₂, triethylamine / CH₂Cl₂ / -40 °C

2: tetrahydrofuran / -78 °C

With thionyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00021a008