4-(2-(4-(2,3-difluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

Base Information

Chemical Name:4-(2-(4-(2,3-difluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile
CAS No.:1598417-26-5
Molecular Formula:C₂₆H₂₈F₂N₄O
Molecular Weight:450.531
Hs Code.:

Synonyms:4-(2-(4-(2,3-difluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

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Chemical Property of 4-(2-(4-(2,3-difluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

Chemical Property:

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Technology Process of 4-(2-(4-(2,3-difluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

There total 11 articles about 4-(2-(4-(2,3-difluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872714-54-0
4-ethenyl-6-(methyloxy)-3-quinolinecarbonitrile

: (2,3-difluoro-4-methyl-benzyl)-piperidin-4-yl-amine hydrochloride

: 1598417-26-5
4-(2-(4-(2,3-difluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

Guidance literature:: With N,N,N',N'-tetramethylguanidine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1598417-26-5
4-(2-(4-(2,3-difluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) isopropylate / ethanol / 0 - 20 °C

1.2: 3 h / 20 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 0 - 20 °C

3.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 3 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; N,N,N',N'-tetramethylguanidine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 245536-50-9
2,3-difluoro-4-methyl-benzaldehyde

: 1598417-26-5
4-(2-(4-(2,3-difluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) isopropylate / ethanol / 0 - 20 °C

1.2: 3 h / 20 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 0 - 20 °C

3.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 3 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; N,N,N',N'-tetramethylguanidine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;