Technology Process of 6-methoxy-4-vinylquinoline-3-carbonitrile
There total 7 articles about 6-methoxy-4-vinylquinoline-3-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane;
at 85 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ethanol / 4 h / 85 °C
2.1: Dowtherm A / 3 h / 250 °C
3.1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C
4.1: sodium hydroxide / tetrahydrofuran / 0 - 20 °C
5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
5.2: 2 h / 0 °C
6.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 6 h / 80 °C
With
tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; Dowtherm A; phosphorus tribromide; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; sodium hydroxide;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Dowtherm A / 3 h / 250 °C
2.1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C
3.1: sodium hydroxide / tetrahydrofuran / 0 - 20 °C
4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
4.2: 2 h / 0 °C
5.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
6.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 6 h / 80 °C
With
tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; Dowtherm A; phosphorus tribromide; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; sodium hydroxide;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;