Technology Process of 5-((6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzo[d]-imidazol-2-yl)oxy)-2-methylbenzoic acid
There total 9 articles about 5-((6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzo[d]-imidazol-2-yl)oxy)-2-methylbenzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Methyl 5-{[6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yl]oxy}-2-methylbenzoate;
With
water; sodium hydroxide;
In
methanol;
at 45 ℃;
for 1h;
With
hydrogenchloride;
In
water;
pH=1;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: acetic acid; N-iodo-succinimide / 50 °C
2: iron; ammonium chloride / ethanol; water / 50 °C / Inert atmosphere
3: potassium hydroxide / ethanol / 3 h / Reflux
4: potassium carbonate / acetone / 1 h / 0 - 20 °C
5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C
6: triethylamine / tetrahydrofuran / 1 h / 20 °C
7: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
8: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; N,N-dimethyl-formamide / 0.75 h / 120 °C / Inert atmosphere
9: tetrabutyl ammonium fluoride / tetrahydrofuran / 4.75 h / 80 °C
10: sodium hydroxide / water; methanol / 1 h / 45 °C
With
N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; iron; potassium carbonate; ammonium chloride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/acs.jmedchem.7b01344
- Guidance literature:
-
Multi-step reaction with 9 steps
1: iron; ammonium chloride / ethanol; water / 50 °C / Inert atmosphere
2: potassium hydroxide / ethanol / 3 h / Reflux
3: potassium carbonate / acetone / 1 h / 0 - 20 °C
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C
5: triethylamine / tetrahydrofuran / 1 h / 20 °C
6: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
7: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; N,N-dimethyl-formamide / 0.75 h / 120 °C / Inert atmosphere
8: tetrabutyl ammonium fluoride / tetrahydrofuran / 4.75 h / 80 °C
9: sodium hydroxide / water; methanol / 1 h / 45 °C
With
tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; iron; potassium carbonate; ammonium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/acs.jmedchem.7b01344
