335349-57-0Relevant articles and documents
Compound with AMPK agonistic activity and preparation and application of prodrug thereof
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Paragraph 0514; 0520-0521, (2021/10/27)
The invention relates to a compound with AMPK agonistic activity and a prodrug thereof, and as well as a preparation method and medical application of a prodrug thereof. The compound has the structure shown in the formula (I), and the prodrug of the compound has the structure shown in the formula (II), wherein each group and the substituent are as defined in the specification. The invention discloses a preparation method of the compound and application of the compound in prevention and treatment AMPK related diseases, and the AMPK related diseases include, but are not limited to, energy metabolism abnormality related diseases. Neurodegenerative diseases and inflammation-related diseases and the like.
Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase
Feng, Danqing,Biftu, Tesfaye,Romero, F. Anthony,Kekec, Ahmet,Dropinski, James,Kassick, Andrew,Xu, Shiyao,Kurtz, Marc M.,Gollapudi, Anantha,Shao, Qing,Yang, Xiaodong,Lu, Ku,Zhou, Gaochao,Kemp, Daniel,Myers, Robert W.,Guan, Hong-Ping,Trujillo, Maria E.,Li, Cai,Weber, Ann,Sebhat, Iyassu K.
supporting information, p. 39 - 44 (2018/05/04)
5′-Adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of mammalian energy homeostasis and has been implicated in mediating many of the beneficial effects of exercise and weight loss including lipid and glucose trafficking. As such,
SUBSTITUTED HETEROARYLBENZIMIDAZOLE COMPOUNDS
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Page/Page column 183, (2018/01/17)
The present invention covers substituted heteroarylbenzimidazole compounds of general formula (I) : in which R1, R2, R3, R4, R5, R6a and R6b are as defined herein, methods of pre