5-<(2'-cyanobiphenyl-4-yl)methyl>-4-hydrazino-2-methyl-6-n-propylpyrimidine

Base Information

• Chemical Name: 5-<(2'-cyanobiphenyl-4-yl)methyl>-4-hydrazino-2-methyl-6-n-propylpyrimidine
• CAS No.: 148474-44-6
• Molecular Formula: C₂₂H₂₃N₅
• Molecular Weight: 357.458
• Mol file: 148474-44-6.mol

Synonyms:5-<(2'-cyanobiphenyl-4-yl)methyl>-4-hydrazino-2-methyl-6-n-propylpyrimidine

Chemical Property of 5-<(2'-cyanobiphenyl-4-yl)methyl>-4-hydrazino-2-methyl-6-n-propylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-<(2'-cyanobiphenyl-4-yl)methyl>-4-hydrazino-2-methyl-6-n-propylpyrimidine

There total 6 articles about 5-<(2'-cyanobiphenyl-4-yl)methyl>-4-hydrazino-2-methyl-6-n-propylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine (141309-93-5) → 5-<(2'-cyanobiphenyl-4-yl)methyl>-4-hydrazino-2-methyl-6-n-propylpyrimidine (148474-44-6)

Guidance literature:

With hydrazine; In ethanol; for 2h; Heating;

DOI:10.1021/jm00041a016

Reference yield:

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile (114772-54-2) → 5-<(2'-cyanobiphenyl-4-yl)methyl>-4-hydrazino-2-methyl-6-n-propylpyrimidine (148474-44-6)

Guidance literature:

Multi-step reaction with 4 steps

1: LiCl, (i-Pr)2NEt / tetrahydrofuran / 15 h / Heating

2: NaOMe / methanol / a) RT, 20 h, b) reflux, 2 h

3: POCl₃ / toluene / 8 h / Heating

4: NH₂NH₂*H₂O / ethanol / 2 h / Heating

With sodium methylate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; lithium chloride; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; toluene;

DOI:10.1002/jhet.5570330450

Reference yield:

ethyl butyroyl acetate (3249-68-1) → 5-<(2'-cyanobiphenyl-4-yl)methyl>-4-hydrazino-2-methyl-6-n-propylpyrimidine (148474-44-6)

Guidance literature:

Multi-step reaction with 4 steps

1: LiCl, (i-Pr)2NEt / tetrahydrofuran / 15 h / Heating

2: NaOMe / methanol / a) RT, 20 h, b) reflux, 2 h

3: POCl₃ / toluene / 8 h / Heating

4: NH₂NH₂*H₂O / ethanol / 2 h / Heating

With sodium methylate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; lithium chloride; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; toluene;

DOI:10.1002/jhet.5570330450

upstream raw materials:

4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

ethyl butyroyl acetate

ethyl 2-<(2'-cyanobiphenyl-4-yl)methyl>-3-oxohexanoate

Downstream raw materials:

8-<(2'-cyanobiphenyl-4-yl)methyl>-2-mercapto-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine

8-<(2'-cyanobiphenyl-4-yl)methyl>-2,5-dimethyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine

8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-2-(methylamino)-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine

7-n-propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidine