2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone

Base Information

• Chemical Name: 2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone
• CAS No.: 1210859-23-6
• Molecular Formula: C₂₄H₂₁BrF₂N₂O
• Molecular Weight: 471.344
• Mol file: 1210859-23-6.mol

Synonyms:2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone

Chemical Property of 2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone

There total 1 articles about 2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(4-Bromo-phenyl)-(2-fluoro-phenylamino)-acetic acid (1210859-21-4) + (S)-2-(2-fluorophenyl)pyrrolidine hydrochloride (1210859-27-0) → 2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone (1210859-23-6)

Guidance literature:

With triethylamine; HATU; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 83.0%

2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone (1210859-23-6) + 3-pyridylboronic acid (1692-25-7) → 2-(2-Fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-(4-pyridin-3-yl-phenyl)-ethanone (1210856-62-4)

Guidance literature:

With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; water; at 130 ℃; for 0.5h; Microwave irradiation;

Reference yield: 75.0%

2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone (1210859-23-6) + tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate (375853-82-0,286961-14-6) → 4-(4-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (1210856-80-6)

Guidance literature:

With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; water; at 130 ℃; for 0.5h; Microwave irradiation;

upstream raw materials:

(4-Bromo-phenyl)-(2-fluoro-phenylamino)-acetic acid

(S)-2-(2-fluorophenyl)pyrrolidine hydrochloride

Downstream raw materials:

4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid

C₃₂H₂₈F₂N₂O₃

C₃₃H₃₀F₂N₂O₃

2-(2-Fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-(4-pyridin-3-yl-phenyl)-ethanone