4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid

Base Information

Chemical Name:4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid
CAS No.:1210856-74-8
Molecular Formula:C₃₁H₂₆F₂N₂O₃
Molecular Weight:512.556
Hs Code.:

Synonyms:4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid

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Chemical Property of 4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid

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Technology Process of 4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid

There total 3 articles about 4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 1210859-23-6
2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1210856-74-8
4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid

: 1210859-32-7
C₃₂H₂₈F₂N₂O₃

: 1210859-34-9
C₃₃H₃₀F₂N₂O₃

Guidance literature:: ethanol; 2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone; 4-methoxycarbonylphenylboronic acid; With water; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; at 130 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In ethanol; water; ethyl acetate;

Reference yield:

: 1210859-32-7
C₃₂H₂₈F₂N₂O₃

: 1210859-34-9
C₃₃H₃₀F₂N₂O₃

: 1210856-74-8
4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid

Guidance literature:: C₃₂H₂₈F₂N₂O₃; C₃₃H₃₀F₂N₂O₃; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 2.5h;

With hydrogenchloride; In methanol; water; ethyl acetate; pH=2;

Reference yield:

: 1210859-23-6
2-(4-Bromo-phenyl)-2-(2-fluoro-phenylamino)-1-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-ethanone

: 14047-29-1
4-carboxyphenylboronic acid

: 1210856-74-8
4'-{1-(2-Fluoro-phenylamino)-2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-biphenyl-4-carboxylic acid

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In ethanol; water; at 130 ℃; Microwave irradiation;
DOI:10.1016/j.bmcl.2013.01.062