1-(1-{2-methoxy-4-[1-(2-methylpyridin-3-ylcarbonyl)piperidin-4-yloxy]benzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one

Base Information

Chemical Name:1-(1-{2-methoxy-4-[1-(2-methylpyridin-3-ylcarbonyl)piperidin-4-yloxy]benzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one
CAS No.:208517-38-8
Molecular Formula:C₃₃H₃₆N₄O₆
Molecular Weight:584.672
Hs Code.:

Synonyms:1-(1-{2-methoxy-4-[1-(2-methylpyridin-3-ylcarbonyl)piperidin-4-yloxy]benzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one

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Chemical Property of 1-(1-{2-methoxy-4-[1-(2-methylpyridin-3-ylcarbonyl)piperidin-4-yloxy]benzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one

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Technology Process of 1-(1-{2-methoxy-4-[1-(2-methylpyridin-3-ylcarbonyl)piperidin-4-yloxy]benzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one

There total 13 articles about 1-(1-{2-methoxy-4-[1-(2-methylpyridin-3-ylcarbonyl)piperidin-4-yloxy]benzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 3222-56-8
2-methylnicotinic acid

: L 371209 hydrochloride

: 208517-38-8
1-(1-{2-methoxy-4-[1-(2-methylpyridin-3-ylcarbonyl)piperidin-4-yloxy]benzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 18h; Ambient temperature;
DOI:10.1021/jm9800797

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 208517-38-8
1-(1-{2-methoxy-4-[1-(2-methylpyridin-3-ylcarbonyl)piperidin-4-yloxy]benzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: AcOH / toluene / 6 h / Heating

2: NaCNBH₃, AcOH / toluene; tetrahydrofuran / 24 h / Ambient temperature

3: 75 percent / DIEA / tetrahydrofuran / 73 h / 0 - 20 °C

4: 95 percent / HCl gas / ethyl acetate / 2 h / 0 - 20 °C

5: 90 percent / HOBT, EDC, DIEA / dimethylformamide / 24 h / Ambient temperature

6: 99 percent / gas HCl / ethyl acetate / 1 h / 0 °C

7: 89 percent / HOBT, DIEA, EDC / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9800797

Reference yield:

: 2150-47-2
methyl 2,4-dihydroxybenzoate

: 208517-38-8
1-(1-{2-methoxy-4-[1-(2-methylpyridin-3-ylcarbonyl)piperidin-4-yloxy]benzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / DEAD, Ph₃P / tetrahydrofuran / 24 h / 0 - 20 °C

2: 89 percent / NaH / dimethylformamide / 18 h / Ambient temperature

3: 95 percent / 2N aq. NaOH / methanol / 3 h / 70 °C

4: 90 percent / HOBT, EDC, DIEA / dimethylformamide / 24 h / Ambient temperature

5: 99 percent / gas HCl / ethyl acetate / 1 h / 0 °C

6: 89 percent / HOBT, DIEA, EDC / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9800797