3-(4-Fluoro-phenyl)-4-nitro-2-(triphenyl-λ⁵-phosphanylidene)-butyric acid ethyl ester

Base Information

• Chemical Name: 3-(4-Fluoro-phenyl)-4-nitro-2-(triphenyl-λ⁵-phosphanylidene)-butyric acid ethyl ester
• CAS No.: 37709-91-4
• Molecular Formula: C₃₀H₂₇FNO₄P
• Molecular Weight: 515.521

Synonyms:3-(4-Fluoro-phenyl)-4-nitro-2-(triphenyl-λ⁵-phosphanylidene)-butyric acid ethyl ester

Chemical Property of 3-(4-Fluoro-phenyl)-4-nitro-2-(triphenyl-λ⁵-phosphanylidene)-butyric acid ethyl ester

Chemical Property:

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Technology Process of 3-(4-Fluoro-phenyl)-4-nitro-2-(triphenyl-λ⁵-phosphanylidene)-butyric acid ethyl ester

There total 1 articles about 3-(4-Fluoro-phenyl)-4-nitro-2-(triphenyl-λ⁵-phosphanylidene)-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-β-nitrostyrene (5153-69-5,706-08-1) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → 3-(4-Fluoro-phenyl)-4-nitro-2-(triphenyl-λ5-phosphanylidene)-butyric acid ethyl ester (37709-91-4)

Guidance literature:

DOI:10.1021/jo00945a040

Reference yield: 72.0%

3-(4-Fluoro-phenyl)-4-nitro-2-(triphenyl-λ5-phosphanylidene)-butyric acid ethyl ester (37709-91-4) + acetyl chloride (75-36-5) → ethyl 2-(1-(4-fluorophenyl)-2-nitroethyl)buta-2,3-dienoate

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01299

Reference yield:

3-(4-Fluoro-phenyl)-4-nitro-2-(triphenyl-λ5-phosphanylidene)-butyric acid ethyl ester (37709-91-4) → (Z)-ethyl 4-(4-fluorophenyl)-5-(hydroxyimino)-2-methyl-4,5-dihydrofuran-3-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: diphenyl(methyl)phosphine / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

With triethylamine; diphenyl(methyl)phosphine; In dichloromethane; acetonitrile;

DOI:10.1021/acs.orglett.6b01299

upstream raw materials:

4-fluoro-β-nitrostyrene

ethyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

C₂₅H₂₆FNO₇

C₂₅H₂₆FNO₇

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