1-(2,6-Dichlorobenzyl)piperazine

Base Information

• Chemical Name: 1-(2,6-Dichlorobenzyl)piperazine
• CAS No.: 102292-50-2
• Molecular Formula: C11H14Cl2N2
• Molecular Weight: 245.152
• Hs Code.: 2933599090
• European Community (EC) Number: 624-497-4
• DSSTox Substance ID: DTXSID80354376
• Wikidata: Q72465674
• Mol file: 102292-50-2.mol

Synonyms:1-(2,6-Dichlorobenzyl)piperazine;102292-50-2;1-[(2,6-dichlorophenyl)methyl]piperazine;1-(2,6-Dichloro-benzyl)-piperazine;1-(2,6-Dichlorobenzyl)-piperazine;MFCD02736281;Piperazine, 1-[(2,6-dichlorophenyl)methyl]-;2,6-dichlorobenzylpiperazine;Oprea1_042275;Oprea1_177202;SCHEMBL2306473;DTXSID80354376;WQTPGHSKQDVCQQ-UHFFFAOYSA-N;BBL037000;STK148781;AKOS000305133;CS-W001041;1-(2,6-Dichlorobenzyl)piperazine, 97%;AS-11228;SY045847;BB 0249458;FT-0653049;EN300-762752;F14601;AB00112646-01;A800556

Chemical Property of 1-(2,6-Dichlorobenzyl)piperazine

Chemical Property:

• Vapor Pressure: 0.000146mmHg at 25°C
• Melting Point: 54-62 °C
• Refractive Index: 1.571
• Boiling Point: 332.4 °C at 760 mmHg
• PKA: 9.02±0.10(Predicted)
• Flash Point: 154.8 °C
• PSA: 15.27000
• Density: 1.252 g/cm³
• LogP: 2.66530
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 244.0534038
• Heavy Atom Count: 15
• Complexity: 185

Purity/Quality:

97% ^*data from raw suppliers

1-(2,6-Dichlorobenzyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)CC2=C(C=CC=C2Cl)Cl

Technology Process of 1-(2,6-Dichlorobenzyl)piperazine

There total 5 articles about 1-(2,6-Dichlorobenzyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

piperazine (110-85-0) + 1,3-Dichloro-2-chloromethyl-benzene (2014-83-7) → 1-[(2,6-dichlorophenyl)methyl]piperazine (102292-50-2)

Guidance literature:

In tetrahydrofuran; for 4h; Reflux;

DOI:10.1016/j.ejmech.2011.01.020

Reference yield: 94.0%

tert-butyl 4-[(2,6-dichlorophenyl)methyl]piperazine-1-carboxylate → 1-[(2,6-dichlorophenyl)methyl]piperazine (102292-50-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 50.0%

piperazine (110-85-0) + 2,6-Dichlorobenzyl bromide (20443-98-5) → 1-[(2,6-dichlorophenyl)methyl]piperazine (102292-50-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 24h;

upstream raw materials:

piperazine

1,3-Dichloro-2-chloromethyl-benzene

2,6-Dichlorobenzyl bromide

Downstream raw materials:

4-[[4-[(2,6-Dichlorophenyl)methyl]-1-piperazinyl]acetyl]-4.5-dihydro-6-methyl-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, hydrochloride

2-(4-(2,6-dichlorobenzyl)piperazin-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamide

1-{2-[4-(2,6-dichlorobenzyl)piperazin-1-yl]-2-oxoethyl}-3,3-diphenylpyrrolidin-2-one

C₂₅H₂₅Cl₂N₇O₂

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 102292-50-2 1-(2,6-Dichlorobenzyl)piperazine

Send

Send

Metric Ton KG G Pound L ML

Send

Send