4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide

Base Information

Chemical Name:4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide
CAS No.:1835283-94-7
Molecular Formula:C₃₆H₄₁Cl₂F₃N₆O₂
Molecular Weight:717.662
Hs Code.:

4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide

Synonyms:

Suppliers and Price of 4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Pan-RAS-IN-1 >98%
100 mg
$ 1500.00

DC Chemicals
Pan-RAS-IN-1 >98%
250 mg
$ 3000.00

ChemScene
Pan-RAS-IN-1 99.87%
100mg
$ 4080.00

ChemScene
Pan-RAS-IN-1 99.87%
50mg
$ 2340.00

ChemScene
Pan-RAS-IN-1 99.87%
25mg
$ 1440.00

ChemScene
Pan-RAS-IN-1 99.87%
10mg
$ 720.00

ChemScene
Pan-RAS-IN-1 99.87%
5mg
$ 420.00

ChemScene
Pan-RAS-IN-1 99.87%
1mg
$ 180.00

Total 5 raw suppliers

Chemical Property of 4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide

Chemical Property:

Boiling Point:809.7±65.0 °C(Predicted)
Density:1.38±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Pan-RAS-IN-1 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide

There total 12 articles about 4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: tert-butyl 4-amino-4-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propylcarbamoyl)piperidine-1-carboxylate

: 1835283-94-7
4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 6h;

Reference yield:

: tert-butyl 3-(5-formyl-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propylcarbamate

: 1835283-94-7
4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) chloride / 1,2-dichloro-ethane / 2 h / 60 °C

1.2: 6 h / 60 °C

2.1: hydrogenchloride / 1,4-dioxane / 24 h

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 6 h / 25 °C

4.1: piperidine / methanol / 24 h

5.1: hydrogenchloride / 1,4-dioxane / 6 h / 25 °C

With piperidine; hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; In 1,4-dioxane; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: tert-butyl N-[3-[5-[[4-[(2,6-dichlorophenyl)methyl]piperazin-1-yl]methyl]-3-[4-(trifluoromethoxy)phenyl]indol-1-yl]propyl]carbamate

: 1835283-94-7
4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 24 h

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 6 h / 25 °C

3.1: piperidine / methanol / 24 h

4.1: hydrogenchloride / 1,4-dioxane / 6 h / 25 °C

With piperidine; hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;