ethyl 7-(tert-butoxycarbonyl(4-(2-perfluoroctylethyl)benzyloxy)amino)heptanoate

Base Information

• Chemical Name: ethyl 7-(tert-butoxycarbonyl(4-(2-perfluoroctylethyl)benzyloxy)amino)heptanoate
• CAS No.: 1313585-47-5
• Molecular Formula: C₃₁H₃₆F₁₇NO₅
• Molecular Weight: 825.603
• Mol file: 1313585-47-5.mol

Synonyms:ethyl 7-(tert-butoxycarbonyl(4-(2-perfluoroctylethyl)benzyloxy)amino)heptanoate

Chemical Property of ethyl 7-(tert-butoxycarbonyl(4-(2-perfluoroctylethyl)benzyloxy)amino)heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 7-(tert-butoxycarbonyl(4-(2-perfluoroctylethyl)benzyloxy)amino)heptanoate

There total 3 articles about ethyl 7-(tert-butoxycarbonyl(4-(2-perfluoroctylethyl)benzyloxy)amino)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 7-bromoheptanoate (29823-18-5) + tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate (1313585-45-3) → ethyl 7-(tert-butoxycarbonyl(4-(2-perfluoroctylethyl)benzyloxy)amino)heptanoate (1313585-47-5)

Guidance literature:

With caesium carbonate; In acetonitrile; at 45 ℃; for 3h;

DOI:10.1016/j.tet.2011.05.039

Reference yield:

1-(bromomethyl)-4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)benzene → ethyl 7-(tert-butoxycarbonyl(4-(2-perfluoroctylethyl)benzyloxy)amino)heptanoate (1313585-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / -5 - 20 °C / Inert atmosphere; Darkness

2: caesium carbonate / acetonitrile / 3 h / 45 °C

With caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.tet.2011.05.039

Reference yield:

(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)methanol (356055-77-1) → ethyl 7-(tert-butoxycarbonyl(4-(2-perfluoroctylethyl)benzyloxy)amino)heptanoate (1313585-47-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfurous dibromide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere; Darkness

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / -5 - 20 °C / Inert atmosphere; Darkness

3: caesium carbonate / acetonitrile / 3 h / 45 °C

With sulfurous dibromide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.tet.2011.05.039

upstream raw materials:

ethyl 7-bromoheptanoate

tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate

(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)methanol

Downstream raw materials:

ethyl 7-(((4-(2-perfluoroctylethyl)benzyl)oxy)amino)heptanoate hydrochloride

C₃₇H₄₀F₁₇NO₅

2-((7-ethoxy-7-oxoheptyl)amino)-2-(4-isopropylphenyl)acetic acid

7-aminoheptanoic acid ethyl ester