methyl 6-<(1,3-dioxolan-2-yl)methyl>-2,6-dimethyl-1-cyclohexene-1-carboxylate

Base Information

Chemical Name:methyl 6-<(1,3-dioxolan-2-yl)methyl>-2,6-dimethyl-1-cyclohexene-1-carboxylate
CAS No.:98127-09-4
Molecular Formula:C₁₄H₂₂O₄
Molecular Weight:254.326
Hs Code.:

Synonyms:methyl 6-<(1,3-dioxolan-2-yl)methyl>-2,6-dimethyl-1-cyclohexene-1-carboxylate

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Chemical Property of methyl 6-<(1,3-dioxolan-2-yl)methyl>-2,6-dimethyl-1-cyclohexene-1-carboxylate

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Technology Process of methyl 6-<(1,3-dioxolan-2-yl)methyl>-2,6-dimethyl-1-cyclohexene-1-carboxylate

There total 7 articles about methyl 6-<(1,3-dioxolan-2-yl)methyl>-2,6-dimethyl-1-cyclohexene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3740-59-8
3,4-dihydro-6-methyl-2H-pyran-2-one

: 98127-09-4
methyl 6-<(1,3-dioxolan-2-yl)methyl>-2,6-dimethyl-1-cyclohexene-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 0.5 h, 2.) THF, a) -78 deg C, 4 h, b) 25 deg C, 8 h

2: 1.) CuI / 1.) THF, -20 deg C, 2.) THF, -78 deg C, 1 h

3: 1.) NaH / 1.) ether, 10 min, 2.) ether, 2 h

4: 1.) CuI / 1.) ether, -20 deg C, 2.) ether, 4 h

5: 1.) O₃, 2.) Me₂S / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂, 25 deg C, overnight

6: p-TsOH / benzene / 6 h / Heating

With copper(l) iodide; dimethylsulfide; sodium hydride; toluene-4-sulfonic acid; ozone; lithium diisopropyl amide; In benzene;
DOI:10.1021/jo00221a027

Reference yield:

: 3128-06-1
5-ketohexanoic acid

: 98127-09-4
methyl 6-<(1,3-dioxolan-2-yl)methyl>-2,6-dimethyl-1-cyclohexene-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / SOCl₂ / benzene / 10 h / Heating

2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 0.5 h, 2.) THF, a) -78 deg C, 4 h, b) 25 deg C, 8 h

3: 1.) CuI / 1.) THF, -20 deg C, 2.) THF, -78 deg C, 1 h

4: 1.) NaH / 1.) ether, 10 min, 2.) ether, 2 h

5: 1.) CuI / 1.) ether, -20 deg C, 2.) ether, 4 h

6: 1.) O₃, 2.) Me₂S / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂, 25 deg C, overnight

7: p-TsOH / benzene / 6 h / Heating

With copper(l) iodide; thionyl chloride; dimethylsulfide; sodium hydride; toluene-4-sulfonic acid; ozone; lithium diisopropyl amide; In benzene;
DOI:10.1021/jo00221a027

Reference yield:

: 86891-79-4
methyl 3-methyl-1-oxo-2-cyclohexene-2-carboxylate

: 98127-09-4
methyl 6-<(1,3-dioxolan-2-yl)methyl>-2,6-dimethyl-1-cyclohexene-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) CuI / 1.) THF, -20 deg C, 2.) THF, -78 deg C, 1 h

2: 1.) NaH / 1.) ether, 10 min, 2.) ether, 2 h

3: 1.) CuI / 1.) ether, -20 deg C, 2.) ether, 4 h

4: 1.) O₃, 2.) Me₂S / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂, 25 deg C, overnight

5: p-TsOH / benzene / 6 h / Heating

With copper(l) iodide; dimethylsulfide; sodium hydride; toluene-4-sulfonic acid; ozone; In benzene;
DOI:10.1021/jo00221a027