(S)-4-((R)-1-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(4H)-one

Base Information

• Chemical Name: (S)-4-((R)-1-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(4H)-one
• CAS No.: 1337953-63-5
• Molecular Formula: C₂₀H₁₉NO₃
• Molecular Weight: 321.376
• Mol file: 1337953-63-5.mol

Synonyms:(S)-4-((R)-1-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(4H)-one

Chemical Property of (S)-4-((R)-1-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-((R)-1-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(4H)-one

There total 2 articles about (S)-4-((R)-1-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-phenyl-4-methyl-4H-oxazolin-5-one (51127-13-0,71963-72-9,87480-74-8,13302-43-7) + 3-(p-methoxyphenyl)-2-propen-1-yl methyl carbonate (488151-80-0) → (S)-4-((R)-1-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(4H)-one (1337953-63-5)

Guidance literature:

3-(p-methoxyphenyl)-2-propen-1-yl methyl carbonate; With bis(1,5-cyclooctadiene)diiridium(I) dichloride; O,O’-(R)-1,1’-(dinaphthyl-2,2’-diyl)-N,N’-di-(R,R)-1-(2-methoxyphenyl)ethylphosphoramidite; Ag⁽¹⁺⁾*(x)C₂H₃N*C₂₈H₄₀O₄P^(1-); In toluene; for 0.333333h; Inert atmosphere;

2-phenyl-4-methyl-4H-oxazolin-5-one; In toluene; at 20 ℃; stereoselective reaction; Molecular sieve; Inert atmosphere; Sealed tube;

DOI:10.1021/ja311363a

Reference yield:

2-phenyl-4-methyl-4H-oxazolin-5-one (51127-13-0,71963-72-9,87480-74-8,13302-43-7) + (R)-(-)-1-acetoxy-1-(4-methoxyphenyl)-2-propylene (1337953-72-6) → (R,E)-2-(3-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(2H)-one + (S,E)-2-(3-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(2H)-one (1337953-66-8) + (S)-4-((R)-1-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(4H)-one (1337953-63-5) + (R)-4-((R)-1-(4-methoxyphenyl)allyl)-4-methyl-2-phenyloxazol-5(4H)-one

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; lithium hexamethyldisilazane; In toluene; at 20 - 60 ℃; for 12h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2011.08.016

upstream raw materials:

2-phenyl-4-methyl-4H-oxazolin-5-one

(R)-(-)-1-acetoxy-1-(4-methoxyphenyl)-2-propylene

3-(p-methoxyphenyl)-2-propen-1-yl methyl carbonate