Oxazole-2-carboxylic acid

Base Information

• Chemical Name: Oxazole-2-carboxylic acid
• CAS No.: 33123-68-1
• Molecular Formula: C7H9NO3
• Molecular Weight: 113.07
• Hs Code.: 2934999090
• Mol file: 33123-68-1.mol

Synonyms:Ethyl 5-methyl-1,3-oxazole-2-carboxylate;

Chemical Property of Oxazole-2-carboxylic acid

Chemical Property:

• Boiling Point: 218.083 °C at 760 mmHg
• PKA: -1.08±0.10(Predicted)
• Flash Point: 85.694 °C
• PSA: 52.33000
• Density: 1.14 g/cm³
• LogP: 1.15970

Purity/Quality:

98% ^*data from raw suppliers

Ethyl5-methyloxazole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxazole-2-carboxylic acid

There total 4 articles about Oxazole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl oxo(prop-2-yn-1-ylamino)acetate → ethyl 5-methyloxazole-2-carboxylate (33123-68-1)

Guidance literature:

With triphenylphosphine gold(I)chloride; silver(I) 4-methylbenzenesulfonate; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1002/chem.200902472

Reference yield: 61.9%

ethyl 2-oxo-2-((2-oxopropyl)amino)acetate (33115-97-8) → ethyl 5-methyloxazole-2-carboxylate (33123-68-1)

Guidance literature:

ethyl 2-oxo-2-((2-oxopropyl)amino)acetate; With trichlorophosphate; In toluene; for 16h; Reflux;

With sodium hydrogencarbonate; In water; toluene;

Reference yield:

ethyl 2-((2-hydroxypropyl)amino)-2-oxoacetate (754202-89-6) → ethyl 5-methyloxazole-2-carboxylate (33123-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

2: trichlorophosphate / toluene / 16 h / Reflux

With Dess-Martin periodane; trichlorophosphate; In dichloromethane; toluene;

upstream raw materials:

ethyl 2-((2-hydroxypropyl)amino)-2-oxoacetate

ethyl 2-oxo-2-((2-oxopropyl)amino)acetate

Downstream raw materials:

(5-methyloxazol-2-yl)methanol

Refernces

• 1、 -. "SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF". . . Retrieved 2014/09/29.
• 2、 -. "NOVEL SPIROPIPERIDINE COMPOUNDS". . . Retrieved 2011/06/23.