(+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)hept-3-en-1-ol

Base Information

Chemical Name:(+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)hept-3-en-1-ol
CAS No.:913975-76-5
Molecular Formula:C₂₆H₄₀O₂Si₂
Molecular Weight:440.773
Hs Code.:

Synonyms:(+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)hept-3-en-1-ol

Suppliers and Price of (+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)hept-3-en-1-ol

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Chemical Property of (+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)hept-3-en-1-ol

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Technology Process of (+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)hept-3-en-1-ol

There total 2 articles about (+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)hept-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 913975-70-9
(+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-3-(2,2,2-trimethyl-1,1-diphenyldisilyloxy)hept-4-enyl pivalate

: 913975-76-5
(+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)hept-3-en-1-ol

Guidance literature:: (+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-3-(2,2,2-trimethyl-1,1-diphenyldisilyloxy)hept-4-enyl pivalate; With 1,1,3,3-tetramethylbutane isonitrile; palladium(II) acetylacetonate; In toluene; Heating;

With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/ja063411+

Reference yield:

: 913975-65-2
(+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-3-hydroxyhept-4-enyl pivalate

: 913975-76-5
(+/-)-(E)-7-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)hept-3-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / triethylamine; 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / 20 °C

2.1: 1,1,3,3-tetramethylbutyl isocyanide / Pd(acac)2 / toluene / Heating

2.2: 59 percent / n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

With dmap; 1,1,3,3-tetramethylbutane isonitrile; triethylamine; palladium(II) acetylacetonate; In tetrahydrofuran; toluene;
DOI:10.1021/ja063411+