methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-D-norleucinate

Base Information

Chemical Name:methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-D-norleucinate
CAS No.:1609082-06-5
Molecular Formula:C₂₃H₂₅F₂N₃O₄
Molecular Weight:445.466
Hs Code.:

Synonyms:methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-D-norleucinate

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Chemical Property of methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-D-norleucinate

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Technology Process of methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-D-norleucinate

There total 6 articles about methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-D-norleucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1609081-95-9
rac-methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)norleucinate

: 1609082-05-4
methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-L-norleucinate

: 1609082-06-5
methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-D-norleucinate

Guidance literature:: With Daicel Chiralpak AD-H; In ethanol; at 40 ℃; Resolution of racemate;

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 1609082-06-5
methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-D-norleucinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 24 h / Molecular sieve; Reflux

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 4 h / 20 °C

5.1: Daicel Chiralpak AD-H / ethanol / 40 °C / Resolution of racemate

With 4-methyl-morpholine; water; sodium methylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 85118-00-9
2,6-Difluorobenzyl bromide

: 1609082-06-5
methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)-D-norleucinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: ethanol / 24 h / Molecular sieve; Reflux

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 16 h / 20 °C

4.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 4 h / 20 °C

5.1: Daicel Chiralpak AD-H / ethanol / 40 °C / Resolution of racemate

With 4-methyl-morpholine; water; sodium methylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;