4-(4-chlorophenoxy)benzenesulfonyl Chloride

Base Information

• Chemical Name: 4-(4-chlorophenoxy)benzenesulfonyl Chloride
• CAS No.: 191327-30-7
• Molecular Formula: C12H8Cl2O3S
• Molecular Weight: 303.166
• Hs Code.: 2930909899
• European Community (EC) Number: 673-511-5
• DSSTox Substance ID: DTXSID90374025
• Nikkaji Number: J1.806.856G
• Wikidata: Q82162471
• Mol file: 191327-30-7.mol

Synonyms:4-(4-chlorophenoxy)benzenesulfonyl Chloride;191327-30-7;4-(4-chlorophenoxy)benzene-1-sulfonyl chloride;[4-(4-chlorophenoxy)phenyl]sulfonyl chloride;4-(4-Chloro-phenoxy)-benzenesulfonyl chloride;4-(4-chlorophenyloxy)benzene-sulfonyl chloride;Benzenesulfonylchloride, 4-(4-chlorophenoxy)-;[4-(4-Chlorophenoxy)Phenyl]Sulfonylchloride;4-(4-chlorophenoxy)benzene-1-sulfonylchloride;Benzenesulfonyl chloride, 4-(4-chlorophenoxy)-;SCHEMBL1133769;DTXSID90374025;XOXRXINFTQAJBW-UHFFFAOYSA-N;CS-M1171;AR1958;MFCD01631865;AKOS000166482;PB12239;AS-45243;4(4-chlorophenoxy)benzenesulfonyl chloride;4-(4-Chlorophenoxy)phenylsulfonyl chloride;4-(4-chlorophenoxy) benzenesulfonylchloride;4-(4-chlorophenoxy)-benzenesulfonyl chloride;4-(4-chlorophenoxy)benzenesulphonyl chloride;Benzenesulfonylchloride,4-(4-chlorophenoxy)-;[4-(4-chlorophenoxy)phenyl]sulphonyl chloride;4-(4'-Chlorophenoxy)phenyl sulfonyl chloride;4-(4-chloro-phenoxy)-benzene sulfonyl chloride;EN300-218378;4-(4-Chlorophenoxy)benzenesulfonic acid chloride;A911806;J-012368

Chemical Property of 4-(4-chlorophenoxy)benzenesulfonyl Chloride

Chemical Property:

• Vapor Pressure: 3.94E-06mmHg at 25°C
• Refractive Index: 1.603
• Boiling Point: 396.3 °C at 760 mmHg
• Flash Point: 193.5 °C
• PSA: 51.75000
• Density: 1.453 g/cm³
• LogP: 5.14060
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 301.9571207
• Heavy Atom Count: 18
• Complexity: 350

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Chlorophenoxy)benzenesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1OC2=CC=C(C=C2)Cl)S(=O)(=O)Cl
• Uses: 4-(4-Chlorophenoxy)benzenesulfonyl Chloride is used in the synthesis of a series of 1-Hydroxy-2-pyridinones, which has an excellent in vitro potency in inhibiting matrix metalloproteinase-9 (MMP-9) for the treatment of ischemic stroke.

Technology Process of 4-(4-chlorophenoxy)benzenesulfonyl Chloride

There total 4 articles about 4-(4-chlorophenoxy)benzenesulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

diphenylether (101-84-8) → 4-(4'-chlorophenoxy)phenylsulfonyl chloride (191327-30-7)

Guidance literature:

diphenylether; With chlorosulfonic acid;

With sulfuryl dichloride;

Reference yield: 38.0%

→ 4-(4'-chlorophenoxy)phenylsulfonyl chloride (191327-30-7)

Guidance literature:

Reference yield: 33.0%

4-chlorodiphenyl ether (7005-72-3) → 4-(4'-chlorophenoxy)phenylsulfonyl chloride (191327-30-7)

Guidance literature:

With chlorosulfonic acid;

upstream raw materials:

diphenylether

4-chlorodiphenyl ether

Downstream raw materials:

2-[4-(4-chloro-phenoxy)-benzenesulfonylamino]-3-hydroxy-propionic acid methyl ester

4-(4-chlorophenoxy)phenylsulfonyl fluoride

4-(4-chlorophenoxy)-N-(2,5-dibromo-pyridin-3-yl)-benzenesulfonamide

1-(tert-butyl) 4-methyl-4-{[4-(4-chlorophenoxy)phenyl]sulfonyl}-1,4-piperidinedicarboxylate