(4R)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]-1-trimethylsilyloxyoxazine

Base Information

Chemical Name:(4R)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]-1-trimethylsilyloxyoxazine
CAS No.:194796-73-1
Molecular Formula:C₁₉H₂₉NO₂Si
Molecular Weight:331.53
Hs Code.:

Synonyms:(4R)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]-1-trimethylsilyloxyoxazine

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Chemical Property of (4R)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]-1-trimethylsilyloxyoxazine

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Technology Process of (4R)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]-1-trimethylsilyloxyoxazine

There total 6 articles about (4R)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]-1-trimethylsilyloxyoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 194796-72-0
(3R,5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)-2-trimethylsilyloxymorpholine

: 194796-73-1
(4R)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]-1-trimethylsilyloxyoxazine

Guidance literature:: With zinc dibromide; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(98)00486-4

Reference yield:

: 97997-96-1
(Z)-6-(trimethylsilyl)hex-4-enyl methanesulfonate

: 194796-73-1
(4R)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]-1-trimethylsilyloxyoxazine

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / (i-Pr)2NH / acetonitrile / 240 h / Heating

2: tetrahydrofuran / 18.5 h

3: 60 percent / Et₃N / tetrahydrofuran / 24 h / 0 - 20 °C

4: 60 percent / ZnBr₂ / CH₂Cl₂ / 1 h / 20 °C

With triethylamine; diisopropylamine; zinc dibromide; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Substitution / 2: Condensation / 3: Substitution / 4: Cyclization;
DOI:10.1016/S0040-4020(98)00486-4

Reference yield:

: 194796-71-9
(5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)morpholin-2-ol

: 194796-73-1
(4R)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]-1-trimethylsilyloxyoxazine

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / Et₃N / tetrahydrofuran / 24 h / 0 - 20 °C

2: 60 percent / ZnBr₂ / CH₂Cl₂ / 1 h / 20 °C

With triethylamine; zinc dibromide; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Cyclization;
DOI:10.1016/S0040-4020(98)00486-4