(3R,5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)-2-trimethylsilyloxymorpholine

Base Information

• Chemical Name: (3R,5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)-2-trimethylsilyloxymorpholine
• CAS No.: 194796-72-0
• Molecular Formula: C₂₈H₄₃NO₂SSi₂
• Molecular Weight: 513.892

Synonyms:(3R,5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)-2-trimethylsilyloxymorpholine

Chemical Property of (3R,5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)-2-trimethylsilyloxymorpholine

Chemical Property:

Purity/Quality:

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Technology Process of (3R,5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)-2-trimethylsilyloxymorpholine

There total 6 articles about (3R,5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)-2-trimethylsilyloxymorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

chloro-trimethyl-silane (75-77-4) + (5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)morpholin-2-ol (194796-71-9) → (3R,5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)-2-trimethylsilyloxymorpholine (194796-72-0)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1055/s-1997-5752

Reference yield:

(Z)-6-(trimethylsilyl)hex-4-enyl methanesulfonate (97997-96-1) → (3R,5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)-2-trimethylsilyloxymorpholine (194796-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / (i-Pr)2NH / acetonitrile / 240 h / Heating

2: tetrahydrofuran / 18.5 h

3: 60 percent / Et₃N / tetrahydrofuran / 24 h / 0 - 20 °C

With triethylamine; diisopropylamine; In tetrahydrofuran; acetonitrile; 1: Substitution / 2: Condensation / 3: Substitution;

DOI:10.1016/S0040-4020(98)00486-4

Reference yield:

(2R)-2-phenyl-2-(6-trimethylsilanylhex-4-enylamino)ethanol (194796-70-8) → (3R,5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)-2-trimethylsilyloxymorpholine (194796-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 18.5 h

2: 60 percent / Et₃N / tetrahydrofuran / 24 h / 0 - 20 °C

With triethylamine; In tetrahydrofuran; 1: Condensation / 2: Substitution;

DOI:10.1016/S0040-4020(98)00486-4

upstream raw materials:

chloro-trimethyl-silane

(5R)-5-phenyl-3-phenylsulfanyl-4-(6-trimethylsilanylhex-4-enyl)morpholin-2-ol

D-2-phenylglycinol

(Z)-6-(trimethylsilyl)hex-4-enyl methanesulfonate

Downstream raw materials:

(4R)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]-1-trimethylsilyloxyoxazine

(4R,9S,9aR)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]oxazin-1-ol

(4R,9S,9aR)-4-phenyl-9-vinyloctahydropyrido[2,1-c][1,4]oxazin-1-one

(2R,3S)-3-Vinyl-piperidine-1,2-dicarboxylic acid 2-(2-chloro-2-phenyl-ethyl) ester 1-vinyl ester

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