(3R)-3-(3,4-dimethoxyphenyl)-1-methyl-3-[(2-phenylmethoxy)ethyl]cyclopentene

Base Information

Chemical Name:(3R)-3-(3,4-dimethoxyphenyl)-1-methyl-3-[(2-phenylmethoxy)ethyl]cyclopentene
CAS No.:321351-48-8
Molecular Formula:C₂₃H₂₈O₃
Molecular Weight:352.474
Hs Code.:

Synonyms:(3R)-3-(3,4-dimethoxyphenyl)-1-methyl-3-[(2-phenylmethoxy)ethyl]cyclopentene

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Chemical Property of (3R)-3-(3,4-dimethoxyphenyl)-1-methyl-3-[(2-phenylmethoxy)ethyl]cyclopentene

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Technology Process of (3R)-3-(3,4-dimethoxyphenyl)-1-methyl-3-[(2-phenylmethoxy)ethyl]cyclopentene

There total 5 articles about (3R)-3-(3,4-dimethoxyphenyl)-1-methyl-3-[(2-phenylmethoxy)ethyl]cyclopentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 321351-47-7
(5R)-1-chloro-5-(3,4-dimethoxyphenyl)-2-methyl-7-(phenylmethoxy)hept-1-en-1-ol

: 321351-48-8
(3R)-3-(3,4-dimethoxyphenyl)-1-methyl-3-[(2-phenylmethoxy)ethyl]cyclopentene

Guidance literature:: With potassium hexamethylsilazane; In diethyl ether; toluene; at 20 ℃; for 17h;
DOI:10.1021/jo001237g

Reference yield:

: 2859-78-1
4-Bromoveratrole

: 321351-48-8
(3R)-3-(3,4-dimethoxyphenyl)-1-methyl-3-[(2-phenylmethoxy)ethyl]cyclopentene

Guidance literature:: Multi-step reaction with 5 steps

1.1: Mg / tetrahydrofuran

1.2: 94 percent / CuBr-Me₂S; Me₂S / tetrahydrofuran / 0.17 h / -15 °C

2.1: 96 percent / 30percent H₂O₂; LiOH*H₂O / H₂O; tetrahydrofuran / 2 h / 0 °C

3.1: 89 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

4.1: NaH / dimethylformamide / 0.5 h / 20 °C

4.2: 84 percent / 17 h / 20 °C

5.1: 85 percent / KHMDS / diethyl ether; toluene / 17 h / 20 °C

With lithium hydroxide; lithium aluminium tetrahydride; potassium hexamethylsilazane; sodium hydride; magnesium; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo001237g

Reference yield:

: 321351-46-6
(3R)-7-chloro-3-(3,4-dimethoxyphenyl)-6-methylhept-6-en-1-ol

: 321351-48-8
(3R)-3-(3,4-dimethoxyphenyl)-1-methyl-3-[(2-phenylmethoxy)ethyl]cyclopentene

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 84 percent / 17 h / 20 °C

2.1: 85 percent / KHMDS / diethyl ether; toluene / 17 h / 20 °C

With potassium hexamethylsilazane; sodium hydride; In diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo001237g