(Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester

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Chemical Name:(Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester
CAS No.:126110-74-5
Molecular Formula:C₄₆H₄₉N₂O₁₀P
Molecular Weight:820.876
Hs Code.:

Synonyms:(Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester

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Chemical Property of (Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester

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Technology Process of (Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester

There total 10 articles about (Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {Benzo[1,3]dioxol-5-yl-[(S)-6-benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-amino}-acetic acid benzhydryl ester

: 126110-74-5
(Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester

Guidance literature:: With sodium periodate; In 1,4-dioxane; water; for 16h; Yield given; Ambient temperature;
DOI:10.1021/jm00167a028

Reference yield:

: 86552-32-1
(4-phenylbutyl)phosphinic acid

: 126110-74-5
(Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

2: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

With dmap; sodium periodate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm00167a028

Reference yield:

: 126132-93-2
benzo[d][1,3]dioxol-5-ylglycine methyl ester

: 126110-74-5
(Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) pyridine / tetrahydrofuran / 1.) room temp., 16 h, 2.) room temp., 24 h

2: 1 N LiOH / dioxane / 1 h / Ambient temperature

3: ethyl acetate / 48 h / Ambient temperature

4: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

5: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

With pyridine; dmap; lithium hydroxide; sodium periodate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;
DOI:10.1021/jm00167a028