({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-benzo[1,3]dioxol-5-yl-amino)-acetic acid

Base Information

Chemical Name:({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-benzo[1,3]dioxol-5-yl-amino)-acetic acid
CAS No.:126110-44-9
Molecular Formula:C₂₅H₃₃N₂O₈P
Molecular Weight:520.519
Hs Code.:

Synonyms:({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-benzo[1,3]dioxol-5-yl-amino)-acetic acid

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Chemical Property of ({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-benzo[1,3]dioxol-5-yl-amino)-acetic acid

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Technology Process of ({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-benzo[1,3]dioxol-5-yl-amino)-acetic acid

There total 10 articles about ({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-benzo[1,3]dioxol-5-yl-amino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126110-74-5
(Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester

: 126110-44-9
({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-benzo[1,3]dioxol-5-yl-amino)-acetic acid

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; for 2h; Yield given;
DOI:10.1021/jm00167a028

Reference yield:

: 86552-32-1
(4-phenylbutyl)phosphinic acid

: 126110-44-9
({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-benzo[1,3]dioxol-5-yl-amino)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

2: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

3: H₂ / 20percent Pd(OH)2/C / methanol / 2 h

With dmap; sodium periodate; hydrogen; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/jm00167a028

Reference yield:

: 126132-93-2
benzo[d][1,3]dioxol-5-ylglycine methyl ester

: 126110-44-9
({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-benzo[1,3]dioxol-5-yl-amino)-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 2.) pyridine / tetrahydrofuran / 1.) room temp., 16 h, 2.) room temp., 24 h

2: 1 N LiOH / dioxane / 1 h / Ambient temperature

3: ethyl acetate / 48 h / Ambient temperature

4: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

5: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

6: H₂ / 20percent Pd(OH)2/C / methanol / 2 h

With pyridine; dmap; lithium hydroxide; sodium periodate; hydrogen; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1021/jm00167a028