ethyl (6-(hydroxymethyl)-4-[2-(4-methoxyphenyl)ethynyl]pyridin-2-yl)(phenyl)phosphinate

Base Information

Chemical Name:ethyl (6-(hydroxymethyl)-4-[2-(4-methoxyphenyl)ethynyl]pyridin-2-yl)(phenyl)phosphinate
CAS No.:1417729-11-3
Molecular Formula:C₂₃H₂₂NO₄P
Molecular Weight:407.406
Hs Code.:

Synonyms:ethyl (6-(hydroxymethyl)-4-[2-(4-methoxyphenyl)ethynyl]pyridin-2-yl)(phenyl)phosphinate

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Chemical Property of ethyl (6-(hydroxymethyl)-4-[2-(4-methoxyphenyl)ethynyl]pyridin-2-yl)(phenyl)phosphinate

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Technology Process of ethyl (6-(hydroxymethyl)-4-[2-(4-methoxyphenyl)ethynyl]pyridin-2-yl)(phenyl)phosphinate

There total 9 articles about ethyl (6-(hydroxymethyl)-4-[2-(4-methoxyphenyl)ethynyl]pyridin-2-yl)(phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91668-84-7
2-bromo-6-methylpyridine N-oxide

: 1417729-11-3
ethyl (6-(hydroxymethyl)-4-[2-(4-methoxyphenyl)ethynyl]pyridin-2-yl)(phenyl)phosphinate

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; sulfuric acid / 16 h / 0 - 100 °C

2.1: phosphorus tribromide / chloroform / 16 h / 60 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

4.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

4.2: 0 °C

5.1: 72 h / 140 °C / Inert atmosphere

6.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 16 h / 65 °C / Inert atmosphere

7.1: 3 h / 120 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / tetrahydrofuran / 4 h / 60 °C / Inert atmosphere

9.1: ethanol; sodium / 0.67 h / 40 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; ethanol; sulfuric acid; nitric acid; sodium; phosphorus tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; toluene;
DOI:10.1039/c2cc35247h

Reference yield:

: 1417728-94-9
ethyl (6-methyl-4-nitropyridin-2-yl)(phenyl)phosphinate

: 1417729-11-3
ethyl (6-(hydroxymethyl)-4-[2-(4-methoxyphenyl)ethynyl]pyridin-2-yl)(phenyl)phosphinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

1.2: 0 °C

2.1: 72 h / 140 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 16 h / 65 °C / Inert atmosphere

4.1: 3 h / 120 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / tetrahydrofuran / 4 h / 60 °C / Inert atmosphere

6.1: ethanol; sodium / 0.67 h / 40 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; ethanol; sodium; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform;
DOI:10.1039/c2cc35247h

Reference yield:

: 5315-25-3
2-bromo-6-methylpyridine

: 1417729-11-3
ethyl (6-(hydroxymethyl)-4-[2-(4-methoxyphenyl)ethynyl]pyridin-2-yl)(phenyl)phosphinate

Guidance literature:: Multi-step reaction with 10 steps

1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 18 h / 65 °C / Inert atmosphere

2.1: nitric acid; sulfuric acid / 16 h / 0 - 100 °C

3.1: phosphorus tribromide / chloroform / 16 h / 60 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 125 °C / Inert atmosphere

5.1: Acetyl bromide / 16 h / 70 °C / Inert atmosphere

5.2: 0 °C

6.1: 72 h / 140 °C / Inert atmosphere

7.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 16 h / 65 °C / Inert atmosphere

8.1: 3 h / 120 °C

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / tetrahydrofuran / 4 h / 60 °C / Inert atmosphere

10.1: ethanol; sodium / 0.67 h / 40 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Acetyl bromide; ethanol; sulfuric acid; nitric acid; sodium; phosphorus tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; toluene;
DOI:10.1039/c2cc35247h