2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide

Base Information

Chemical Name:2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide
CAS No.:159518-00-0
Molecular Formula:C₁₅H₁₃Br₂NO₅S
Molecular Weight:479.146
Hs Code.:

2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ<sup>3</sup>-cephem 1,1-dioxide

Synonyms:2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide

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Chemical Property of 2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide

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Technology Process of 2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide

There total 3 articles about 2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 136933-63-6
(6R,7S)-2-Benzoyl-7-methoxy-3-methyl-5,5-dioxo-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-en-8-one

: 159518-00-0
2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 4h; Heating;
DOI:10.1021/jm00049a020

Reference yield:

: 126621-86-1
7α-Methoxy-3-methyl-3-cephem-4-carboxylic acid

: 159518-00-0
2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride, DMF / tetrahydrofuran / 1.5 h / 10 °C

2: 1.) CuI, 3) MCPBA

3: 67 percent / NBS, AIBN / CCl₄ / 4 h / Heating

With N-Bromosuccinimide; copper(l) iodide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane;
DOI:10.1021/jm00049a020

Reference yield:

: 126598-07-0
7α-methoxy-3-methyl-Δ³-cephem-4-carbonyl chloride

: 159518-00-0
2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CuI, 3) MCPBA

2: 67 percent / NBS, AIBN / CCl₄ / 4 h / Heating

With N-Bromosuccinimide; copper(l) iodide; 2,2'-azobis(isobutyronitrile); 3-chloro-benzenecarboperoxoic acid; In tetrachloromethane;
DOI:10.1021/jm00049a020