17β-tert-Butoxy-1,3-dimethoxy-7α-methyl-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien

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Chemical Name:17β-tert-Butoxy-1,3-dimethoxy-7α-methyl-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien
CAS No.:75019-25-9
Molecular Formula:C₃₁H₄₂O₅S
Molecular Weight:526.737
Hs Code.:

Synonyms:17β-tert-Butoxy-1,3-dimethoxy-7α-methyl-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien

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Chemical Property of 17β-tert-Butoxy-1,3-dimethoxy-7α-methyl-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien

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Technology Process of 17β-tert-Butoxy-1,3-dimethoxy-7α-methyl-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien

There total 11 articles about 17β-tert-Butoxy-1,3-dimethoxy-7α-methyl-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 82055-04-7
17β-tert-Butoxy-1,3-dimethoxy-7α-methyl-7β-(phenylsulfonyl)-1,3,5(10),9(11)-oestratetraen

: 75019-25-9
17β-tert-Butoxy-1,3-dimethoxy-7α-methyl-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 12h; under 760 Torr; Ambient temperature;
DOI:10.1002/jlac.198219820306

Reference yield:

: 51168-78-6
(1S,7aS)-1-tert-Butoxy-1,2,3,6,7,7a-hexahydro-7a-methyl-4-<(phenylsulfonyl)methyl>-5H-inden-5-on

: 75019-25-9
17β-tert-Butoxy-1,3-dimethoxy-7α-methyl-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / H₂, 1N HCl / 10percent Pd/C / ethanol

2: 75 percent / conc. H₂SO₄, HC(OC₂H₅)3 / dioxane / 24 h / Ambient temperature

3: 32 percent / LDA / tetrahydrofuran / 12 h / -20 °C

4: 81 percent / (CF₃CO)2O, CF₃COOH / toluene / 0.5 h / Ambient temperature

5: 1) LDA / 1) THF, hexane, 1 h, -20 deg C, 2) THF, -20 deg C, 12 h

6: 83 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 760 Torr / Ambient temperature

With hydrogenchloride; sulfuric acid; hydrogen; orthoformic acid triethyl ester; trifluoroacetic acid; trifluoroacetic anhydride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene;
DOI:10.1002/jlac.198219820306

Reference yield:

: 41878-38-0
(1S,7aS)-1-tert-butoxy-7a-methyl-1,2,3,6,7,7a-hexahydro-5H-inden-5-one

: 75019-25-9
17β-tert-Butoxy-1,3-dimethoxy-7α-methyl-7β-(phenylsulfonyl)-1,3,5(10)-oestratrien

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / tetramethylethylenediamine / acetic acid / 60 h / 35 °C

2: 70 percent / H₂, 1N HCl / 10percent Pd/C / ethanol

3: 75 percent / conc. H₂SO₄, HC(OC₂H₅)3 / dioxane / 24 h / Ambient temperature

4: 32 percent / LDA / tetrahydrofuran / 12 h / -20 °C

5: 81 percent / (CF₃CO)2O, CF₃COOH / toluene / 0.5 h / Ambient temperature

6: 1) LDA / 1) THF, hexane, 1 h, -20 deg C, 2) THF, -20 deg C, 12 h

7: 83 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 760 Torr / Ambient temperature

With hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; hydrogen; orthoformic acid triethyl ester; trifluoroacetic acid; trifluoroacetic anhydride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid; toluene;
DOI:10.1002/jlac.198219820306