(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-d2-trifluoroethoxy)phenoxy)-d4-ethylamino)propyl)indoline-7-carboxamide

Base Information

Chemical Name:(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-d2-trifluoroethoxy)phenoxy)-d4-ethylamino)propyl)indoline-7-carboxamide
CAS No.:1051374-51-6
Molecular Formula:C₂₅H₃₂F₃N₃O₄
Molecular Weight:501.494
Hs Code.:

Synonyms:(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-d2-trifluoroethoxy)phenoxy)-d4-ethylamino)propyl)indoline-7-carboxamide

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Chemical Property of (R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-d2-trifluoroethoxy)phenoxy)-d4-ethylamino)propyl)indoline-7-carboxamide

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Technology Process of (R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-d2-trifluoroethoxy)phenoxy)-d4-ethylamino)propyl)indoline-7-carboxamide

There total 6 articles about (R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-d2-trifluoroethoxy)phenoxy)-d4-ethylamino)propyl)indoline-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1051374-60-7
(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile

: 1051374-51-6,1426173-86-5
(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-d2-trifluoroethoxy)phenoxy)-d4-ethylamino)propyl)indoline-7-carboxamide

Guidance literature:: (R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile; With water; dihydrogen peroxide; In dimethyl sulfoxide; for 0.166667h;

With sodium hydroxide; water; In dimethyl sulfoxide; for 1h;

Reference yield:

: 1051374-62-9
1-methoxy-2-(2,2,2-trifluoro-1-d2-ethoxy)benzene

: 1051374-51-6,1426173-86-5
(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-d2-trifluoroethoxy)phenoxy)-d4-ethylamino)propyl)indoline-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 0.5 h / 0 °C

1.2: 0.17 h / 0 °C

2.1: sodium hydroxide / water / 10 h / 120 °C

3.1: sodium hydrogencarbonate / ethanol / 6 h / 105 °C

4.1: hydrogenchloride; hydrogen / palladium on activated charcoal / ethanol; water / 2 h / 1551.49 Torr

5.1: water; dihydrogen peroxide / dimethyl sulfoxide / 0.17 h

5.2: 1 h

With hydrogenchloride; sodium hydroxide; water; hydrogen; dihydrogen peroxide; boron tribromide; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1051374-63-0
2-(2,2,2-trifluoro-1-d2-ethoxy)phenol

: 1051374-51-6,1426173-86-5
(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-d2-trifluoroethoxy)phenoxy)-d4-ethylamino)propyl)indoline-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 10 h / 120 °C

2.1: sodium hydrogencarbonate / ethanol / 6 h / 105 °C

3.1: hydrogenchloride; hydrogen / palladium on activated charcoal / ethanol; water / 2 h / 1551.49 Torr

4.1: water; dihydrogen peroxide / dimethyl sulfoxide / 0.17 h

4.2: 1 h

With hydrogenchloride; sodium hydroxide; water; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; water; dimethyl sulfoxide;