(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile

Base Information

Chemical Name:(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile
CAS No.:1051374-60-7
Molecular Formula:C₂₅H₃₀F₃N₃O₃
Molecular Weight:483.479
Hs Code.:

Synonyms:(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile

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Chemical Property of (R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile

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Technology Process of (R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile

There total 4 articles about (R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1051374-58-3
(R)-1-(3-(benzyloxy)propyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile

: 1051374-60-7
(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; water; for 2h; under 1551.49 Torr;

Reference yield:

: 1051374-62-9
1-methoxy-2-(2,2,2-trifluoro-1-d2-ethoxy)benzene

: 1051374-60-7
(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 0.5 h / 0 °C

1.2: 0.17 h / 0 °C

2.1: sodium hydroxide / water / 10 h / 120 °C

3.1: sodium hydrogencarbonate / ethanol / 6 h / 105 °C

4.1: hydrogenchloride; hydrogen / palladium on activated charcoal / ethanol; water / 2 h / 1551.49 Torr

With hydrogenchloride; sodium hydroxide; hydrogen; boron tribromide; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; dichloromethane; water;

Reference yield:

: 1051374-63-0
2-(2,2,2-trifluoro-1-d2-ethoxy)phenol

: 1051374-60-7
(R)-1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoro-1-d2-ethoxy)phenoxy)ethyl-d4-amino)propyl)indoline-7-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water / 10 h / 120 °C

2: sodium hydrogencarbonate / ethanol / 6 h / 105 °C

3: hydrogenchloride; hydrogen / palladium on activated charcoal / ethanol; water / 2 h / 1551.49 Torr

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; water;