6-(4-chlorobenzylidene)-N-tert-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-carboxamide

Base Information

Chemical Name:6-(4-chlorobenzylidene)-N-tert-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-carboxamide
CAS No.:1310489-93-0
Molecular Formula:C₂₇H₂₄ClN₃O
Molecular Weight:441.96
Hs Code.:

Synonyms:6-(4-chlorobenzylidene)-N-tert-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-carboxamide

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Chemical Property of 6-(4-chlorobenzylidene)-N-tert-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-carboxamide

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Technology Process of 6-(4-chlorobenzylidene)-N-tert-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-carboxamide

There total 7 articles about 6-(4-chlorobenzylidene)-N-tert-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1310489-89-4
(E)-2-(4-chlorostyryl)-3-(2-bromophenyl)-N-tert-butyl-3,4-dihydroquinazoline-4-carboxamide

: 1310489-93-0
6-(4-chlorobenzylidene)-N-tert-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-carboxamide

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 110 ℃; for 5h;
DOI:10.1016/j.tet.2011.03.056

Reference yield:

: C₄₀H₃₈BrClN₃O₂P

: 1310489-93-0
6-(4-chlorobenzylidene)-N-tert-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 12 h / Reflux

2: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 5 h / 110 °C

With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; toluene; 1: Aza-Wittig reaction / 2: Heck reaction;
DOI:10.1016/j.tet.2011.03.056

Reference yield:

: 1615-02-7,940-62-5
3-(4-chlorophenyl)prop-2-enoic acid

: 1310489-93-0
6-(4-chlorobenzylidene)-N-tert-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 36 h / 20 °C

2: toluene / 2 h

3: toluene / 12 h / Reflux

4: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 5 h / 110 °C

With palladium diacetate; potassium carbonate; triphenylphosphine; In methanol; N,N-dimethyl-formamide; toluene; 1: Ugi condensation / 2: Staudinger reaction / 3: Aza-Wittig reaction / 4: Heck reaction;
DOI:10.1016/j.tet.2011.03.056