(E)-N-(1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(2-bromophenyl)-3-(4-chlorophenyl)acrylamide

Base Information

Chemical Name:(E)-N-(1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(2-bromophenyl)-3-(4-chlorophenyl)acrylamide
CAS No.:1310489-56-5
Molecular Formula:C₂₇H₂₅BrClN₅O₂
Molecular Weight:566.885
Hs Code.:

Synonyms:(E)-N-(1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(2-bromophenyl)-3-(4-chlorophenyl)acrylamide

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Chemical Property of (E)-N-(1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(2-bromophenyl)-3-(4-chlorophenyl)acrylamide

Chemical Property:

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Technology Process of (E)-N-(1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(2-bromophenyl)-3-(4-chlorophenyl)acrylamide

There total 1 articles about (E)-N-(1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(2-bromophenyl)-3-(4-chlorophenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 1615-02-7,940-62-5
3-(4-chlorophenyl)prop-2-enoic acid

: 16714-25-3
2-azidobenzaldehyde

: 615-36-1
2-bromoaniline

: 1310489-56-5
(E)-N-(1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(2-bromophenyl)-3-(4-chlorophenyl)acrylamide

Guidance literature:: In methanol; at 20 ℃; for 36h;
DOI:10.1016/j.tet.2011.03.056

Reference yield:

: 1310489-56-5
(E)-N-(1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(2-bromophenyl)-3-(4-chlorophenyl)acrylamide

: 1486-28-8
diphenyl(methyl)phosphine

: C₄₀H₃₈BrClN₃O₂P

Guidance literature:: In toluene; for 2h;
DOI:10.1016/j.tet.2011.03.056

Reference yield:

: 1310489-56-5
(E)-N-(1-(2-azidophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(2-bromophenyl)-3-(4-chlorophenyl)acrylamide

: 1310489-93-0
6-(4-chlorobenzylidene)-N-tert-butyl-6,12-dihydroindolo[2,1-b]quinazoline-12-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 2 h

2: toluene / 12 h / Reflux

3: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 5 h / 110 °C

With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; toluene; 1: Staudinger reaction / 2: Aza-Wittig reaction / 3: Heck reaction;
DOI:10.1016/j.tet.2011.03.056