(2R)-4-(3,4-dimethoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

Base Information

Chemical Name:(2R)-4-(3,4-dimethoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid
CAS No.:1220353-57-0
Molecular Formula:C₂₀H₂₃NO₅
Molecular Weight:357.406
Hs Code.:

Synonyms:(2R)-4-(3,4-dimethoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-4-(3,4-dimethoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

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Technology Process of (2R)-4-(3,4-dimethoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

There total 1 articles about (2R)-4-(3,4-dimethoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 298-12-4
Glyoxilic acid

: 1131-62-0
1-(3,4-dimethoxyphenyl)ethanone

: 1220353-57-0
(2R)-4-(3,4-dimethoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

Guidance literature:: In ethanol; at 40 ℃; for 144h; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tetasy.2009.12.014

Reference yield:

: 1220353-57-0
(2R)-4-(3,4-dimethoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

: 1273328-68-9
C₂₀H₂₅NO₅

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃;
DOI:10.1021/ol2001057

Reference yield:

: 1220353-57-0
(2R)-4-(3,4-dimethoxyphenyl)-4-oxo-2-{[(1R)-1-phenylethyl]amino}butanoic acid

: 1212986-82-7
(1R,3R)-3-amino-1-(3,4-dimethoxyphenyl)butane-1,4-diol

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 20 °C

2: hydrogenchloride / water / 40 °C

3: potassium carbonate / water

4: sodium tetrahydroborate / ethanol / 20 °C

5: 20 wt% Pd(OH)2/C; hydrogen / methanol / 40 °C

With hydrogenchloride; sodium tetrahydroborate; 20 wt% Pd(OH)2/C; hydrogen; potassium carbonate; In methanol; ethanol; water;
DOI:10.1021/ol2001057