methyl 4-(2-(3-(4-trifluoromethylphenyl)ureido)-6-nitroquinazolin-4-ylamino)benzoate

Base Information

Chemical Name:methyl 4-(2-(3-(4-trifluoromethylphenyl)ureido)-6-nitroquinazolin-4-ylamino)benzoate
CAS No.:1308320-02-6
Molecular Formula:C₂₄H₁₇F₃N₆O₅
Molecular Weight:526.431
Hs Code.:

Synonyms:methyl 4-(2-(3-(4-trifluoromethylphenyl)ureido)-6-nitroquinazolin-4-ylamino)benzoate

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Chemical Property of methyl 4-(2-(3-(4-trifluoromethylphenyl)ureido)-6-nitroquinazolin-4-ylamino)benzoate

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Technology Process of methyl 4-(2-(3-(4-trifluoromethylphenyl)ureido)-6-nitroquinazolin-4-ylamino)benzoate

There total 5 articles about methyl 4-(2-(3-(4-trifluoromethylphenyl)ureido)-6-nitroquinazolin-4-ylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1308319-96-1
methyl 4-(2-amino-6-nitroquinazolin-4-ylamino)benzoate

: 1548-13-6
p-trifluoromethyl-phenylisocyanate

: 1308320-02-6
methyl 4-(2-(3-(4-trifluoromethylphenyl)ureido)-6-nitroquinazolin-4-ylamino)benzoate

Guidance literature:: In 1,4-dioxane; at 120 ℃; for 0.25h; Microwave irradiation;
DOI:10.1016/j.bmc.2011.03.058

Reference yield:

: 1308319-76-7
methyl 4-(2-chloro-6-nitroquinazolin-4-ylamino)benzoate

: 1308320-02-6
methyl 4-(2-(3-(4-trifluoromethylphenyl)ureido)-6-nitroquinazolin-4-ylamino)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / ethanol / 2.25 h / 90 °C / Microwave irradiation

2: 1,4-dioxane / 0.25 h / 120 °C / Microwave irradiation

With ammonia; In 1,4-dioxane; ethanol;
DOI:10.1016/j.bmc.2011.03.058

Reference yield:

: 74173-77-6
2,4-dichloro-6-nitro-quinazoline

: 1308320-02-6
methyl 4-(2-(3-(4-trifluoromethylphenyl)ureido)-6-nitroquinazolin-4-ylamino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane; isopropyl alcohol / 4 h / 20 °C

2: ammonia / ethanol / 2.25 h / 90 °C / Microwave irradiation

3: 1,4-dioxane / 0.25 h / 120 °C / Microwave irradiation

With ammonia; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmc.2011.03.058