Technology Process of methyl 3-(5-bromo-2,4-dimethoxyphenyl)-3-oxopropanoate
There total 2 articles about methyl 3-(5-bromo-2,4-dimethoxyphenyl)-3-oxopropanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
carbonic acid dimethyl ester;
With
sodium hydride;
In
toluene;
Reflux;
1-(5-bromo-2,4-dimethoxyphenyl)ethan-1-one;
In
tetrahydrofuran; toluene;
for 3h;
Reflux;
DOI:10.1002/jhet.2477
- Guidance literature:
-
Multi-step reaction with 2 steps
1: bromine / acetonitrile / 5 h / -15 °C / Inert atmosphere
2: sodium hydride / toluene; mineral oil; tetrahydrofuran / 2 h / 80 °C / Inert atmosphere
With
bromine; sodium hydride;
In
tetrahydrofuran; toluene; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 3 h / 80 °C / Inert atmosphere
2.1: methanol / 1 h / 20 °C
3.1: N,O-bis-(trimethylsilyl)-acetamide / N,N-dimethyl-formamide / 5 h / 100 °C
4.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C
5.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4 h / 90 °C / Inert atmosphere
6.1: water; hydrogenchloride / tetrahydrofuran / 4 h / 20 °C
6.2: 20 °C
With
1H-imidazole; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; N,O-bis-(trimethylsilyl)-acetamide; water;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
