2-Ethylbenzohydrazide

Base Information

• Chemical Name: 2-Ethylbenzohydrazide
• CAS No.: 59635-98-2
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.207
• DSSTox Substance ID: DTXSID30520923
• Wikidata: Q82385098
• Mol file: 59635-98-2.mol

Synonyms:2-ethylbenzohydrazide;59635-98-2;2-Deoxy-L-thymidine;2-ethyl-benzhydrazide;2-ethyl benzo-hydrazide;SCHEMBL3135538;DTXSID30520923;PRGOMJUDGZDSQZ-UHFFFAOYSA-N;AKOS006286203;AC-7807

Chemical Property of 2-Ethylbenzohydrazide

Chemical Property:

• Refractive Index: 1.558
• PSA: 55.12000
• Density: 1.096 g/cm³
• LogP: 1.94370
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 164.094963011
• Heavy Atom Count: 12
• Complexity: 159

Purity/Quality:

99% ^*data from raw suppliers

2-Ethylbenzoicacidhydrazide 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC=CC=C1C(=O)NN

Technology Process of 2-Ethylbenzohydrazide

There total 3 articles about 2-Ethylbenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-ethylbenzoic acid (612-19-1) → 2-ethylbenzoic acid hydrazide (59635-98-2)

Guidance literature:

2-ethylbenzoic acid; With hydrogenchloride; In methanol; Inert atmosphere; Reflux;

With hydrazine hydrate; In ethanol; at 100 ℃; for 4h; Microwave irradiation;

Reference yield:

2-ethylbenzoyl chloride (76118-05-3) → 2-ethylbenzoic acid hydrazide (59635-98-2)

Guidance literature:

With hydrazine hydrate; In ethanol; dichloromethane; for 3h; Yield given; Ambient temperature;

DOI:10.1021/jm00362a018

Reference yield:

N'-(2-Ethyl-benzoyl)-hydrazinecarboxylic acid tert-butyl ester → 2-ethylbenzoic acid hydrazide (59635-98-2)

Guidance literature:

With hydrogenchloride; for 0.5h; Yield given;

DOI:10.1021/jm00362a018

upstream raw materials:

2-ethylbenzoyl chloride

2-ethylbenzoic acid

Downstream raw materials:

5-(3-Allyloxy-phenyl)-3-(2-ethyl-phenyl)-1H-[1,2,4]triazole

5-(2,3-Dimethoxy-phenyl)-3-(2-ethyl-phenyl)-1H-[1,2,4]triazole

5-(3,4-Dimethoxy-phenyl)-3-(2-ethyl-phenyl)-1H-[1,2,4]triazole

5-(3,5-Dimethoxy-phenyl)-3-(2-ethyl-phenyl)-1H-[1,2,4]triazole

Refernces

• 1、 Omodei-Sale, Amedeo,Consonni, Pietro,Galliani, Giulio. "A New Class of Nonhormonal Pregnancy-Terminating Agents. Synthesis and Contragestational Activity of 3,5-Diaryl-s-triazoles". . p. 1187 - 1192. Retrieved 2007/10/02.