ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylsulfinylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Base Information

Chemical Name:ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylsulfinylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate
CAS No.:165808-02-6
Molecular Formula:C₂₆H₂₆N₂O₆S₂
Molecular Weight:526.634
Hs Code.:

Synonyms:ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylsulfinylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

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Chemical Property of ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylsulfinylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

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Technology Process of ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylsulfinylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

There total 6 articles about ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylsulfinylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 165807-75-0
ethyl 2,4(1H,3H)-dioxo-6-(4-methoxyphenyl)-1-(2-methylthiobenzyl)-5-methylthieno[2,3-d]-pyrimidine-3-acetate

: 165808-02-6
ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylsulfinylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1248/cpb.46.1724

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 165808-02-6
ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylsulfinylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: NH₄OAc, AcOH / benzene / 24 h / Heating

2: S, Et₂NH / ethanol / 2 h / 60 °C

3: 1.) pyridine, 2.) NaOEt / 1.) 45 deg C, 3 h, 2.) EtOH, RT, 1.5 h

4: 88 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

5: 72 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; ammonium acetate; sodium ethanolate; potassium carbonate; acetic acid; diethylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.46.1724

Reference yield:

: 26190-68-1
1-chloromethyl-2-methylsulfanylbenzene

: 165808-02-6
ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylsulfinylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

2: 72 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1724