4-(3-chloro-phenyl)-2-(6-formyl-5-methoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

Base Information

Chemical Name:4-(3-chloro-phenyl)-2-(6-formyl-5-methoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide
CAS No.:1232235-12-9
Molecular Formula:C₁₉H₁₃ClN₄O₃S
Molecular Weight:412.856
Hs Code.:

Synonyms:4-(3-chloro-phenyl)-2-(6-formyl-5-methoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

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Chemical Property of 4-(3-chloro-phenyl)-2-(6-formyl-5-methoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

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Technology Process of 4-(3-chloro-phenyl)-2-(6-formyl-5-methoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

There total 5 articles about 4-(3-chloro-phenyl)-2-(6-formyl-5-methoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₅ClN₄O₃S

: 149-73-5
trimethyl orthoformate

: 1232235-12-9
4-(3-chloro-phenyl)-2-(6-formyl-5-methoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

Guidance literature:: C₁₈H₁₅ClN₄O₃S; trimethyl orthoformate; With acetic acid; for 1h;

With potassium carbonate; In ethyl acetate;

Reference yield:

: 1232235-08-3
5-fluoro-2-hydroxy-4-nitro-benzaldehyde

: 1232235-12-9
4-(3-chloro-phenyl)-2-(6-formyl-5-methoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: toluene-4-sulfonic acid / methanol / 1 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

4: hydrogenchloride; water / acetonitrile / 2 h / Reflux

5: ammonium chloride; zinc / tetrahydrofuran / 20 °C

6: acetic acid / 1 h

With hydrogenchloride; water; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; zinc; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1232235-07-2
methanesulfonic acid 2-dimethoxymethyl-4-fluoro-5-nitro-phenyl ester

: 1232235-12-9
4-(3-chloro-phenyl)-2-(6-formyl-5-methoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1: water; potassium hydroxide / dimethyl sulfoxide / 20 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: toluene-4-sulfonic acid / methanol / 1 h / Reflux

4: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

5: hydrogenchloride; water / acetonitrile / 2 h / Reflux

6: ammonium chloride; zinc / tetrahydrofuran / 20 °C

7: acetic acid / 1 h

With hydrogenchloride; water; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; potassium hydroxide; zinc; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;