4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid trifluoroacetic acid

Base Information

• Chemical Name: 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid trifluoroacetic acid
• CAS No.: 1254733-98-6
• Molecular Formula: C₂HF₃O₂*C₃₂H₃₅FN₂O₅
• Molecular Weight: 660.663

Synonyms:4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid trifluoroacetic acid

Chemical Property of 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid trifluoroacetic acid

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid trifluoroacetic acid

There total 7 articles about 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid (1254732-07-4) + trifluoroacetic acid (76-05-1) → 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid trifluoroacetic acid (1254733-98-6)

Guidance literature:

methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid; With lithium hydroxide; In methanol; water; at 50 ℃;

trifluoroacetic acid;

DOI:10.1021/acsmedchemlett.8b00305

Reference yield:

4-{8-[(2,6-diethoxy-4'-fluorobiphenyI-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid (1254730-81-8) + trifluoroacetic acid (76-05-1) → 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid trifluoroacetic acid (1254733-98-6)

Guidance literature:

In water; acetonitrile;

Reference yield:

(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methanol (1227405-83-5) → 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid trifluoroacetic acid (1254733-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1: methanesulfonyl chloride; triethylamine / 18 h / 20 °C

2: N,N-dimethyl-formamide / 20 °C

3: lithium hydroxide / methanol; water / 50 °C

With methanesulfonyl chloride; triethylamine; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/acsmedchemlett.8b00305

upstream raw materials:

4-{8-[(2,6-diethoxy-4'-fluorobiphenyI-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoic acid

trifluoroacetic acid

ethyl 2,6-diethoxy-4'-fluorobiphenyl-4-carboxylate

(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methanol

Downstream raw materials:

C₃₂H₃₆FN₃O₄

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