methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid

Base Information

Chemical Name:methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid
CAS No.:1254732-07-4
Molecular Formula:C₂HF₃O₂*C₃₃H₃₇FN₂O₅
Molecular Weight:674.69
Hs Code.:

Synonyms:methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid

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Chemical Property of methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid

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Technology Process of methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid

There total 6 articles about methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1227405-84-6
4-(chloromethyl)-2,6-diethoxy-4'-fluoro-1,1'-biphenyl

: 1254733-79-3
methyl 4-(3-oxo-2,8-diazaspiro[4.5]dec-2-yl)benzoate hydrochloride

: 1254732-07-4
methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/acsmedchemlett.8b00305

Reference yield:

: 1254732-06-3
C₃₃H₃₇FN₂O₅

: 76-05-1
trifluoroacetic acid

: 1254732-07-4
methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid

Guidance literature:: In water; acetonitrile;

Reference yield:

: 1227405-83-5
(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methanol

: 1254732-07-4
methyl 4-{8-[(2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl]-3-oxo-2,8-diazaspiro[4.5]dec-2-yl}benzoate trifluoroacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonyl chloride; triethylamine / 18 h / 20 °C

2: N,N-dimethyl-formamide / 20 °C

With methanesulfonyl chloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.8b00305