cis-(3S,4R)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one

Base Information

Chemical Name:cis-(3S,4R)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one
CAS No.:144541-26-4
Molecular Formula:C₂₉H₃₅N₃O₆
Molecular Weight:521.613
Hs Code.:

Synonyms:cis-(3S,4R)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one

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Chemical Property of cis-(3S,4R)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one

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Technology Process of cis-(3S,4R)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one

There total 3 articles about cis-(3S,4R)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102308-32-7
(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 144541-26-4
cis-(3S,4R)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: MgSO₄ / CH₂Cl₂ / 4 h / 0 °C

2: 1.)triethylamine / 1.) CH₂Cl₂, toluene, 0 deg C, 2 h, 2.) CH₂Cl₂, toluene, RT, overnight

With magnesium sulfate; triethylamine; In dichloromethane;
DOI:10.1021/ja00050a016

Reference yield:

: 100-46-9
benzylamine

: 144541-26-4
cis-(3S,4R)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: MgSO₄ / CH₂Cl₂ / 4 h / 0 °C

2: 1.)triethylamine / 1.) CH₂Cl₂, toluene, 0 deg C, 2 h, 2.) CH₂Cl₂, toluene, RT, overnight

With magnesium sulfate; triethylamine; In dichloromethane;
DOI:10.1021/ja00050a016

Reference yield:

: 112674-71-2
(R)-(2-oxo-4-phenyl-1,3-oxazolidin-3-yl)acetyl chloride

: 144492-44-4
(R)-4-[(E)-Benzylimino-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 144541-27-5
cis-(3R,4S)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one

: 144541-26-4
cis-(3S,4R)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one

Guidance literature:: With triethylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, toluene, 0 deg C, 2 h, 2.) CH₂Cl₂, toluene, RT, overnight;
DOI:10.1021/ja00050a016