112674-71-2

Upstream product

• 123882-32-6 2-[(R)-2-oxo-4-phenyloxazolidin-3-yl]acetic acid 
• 99333-53-6 ((R)-2-Oxo-4-phenyl-oxazolidin-3-yl)-acetic acid ethyl ester 
• 910322-87-1 benzyl 2-[(R)-2-oxo-4-phenyloxazolidin-3-yl]acetate 
• 90319-52-1 (4R)-phenyl-2-oxazolidinone 

Downstream Products

• 153463-27-5 (R)-3-[(3R,4S)-1-(4-Methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-4-phenyl-oxazolidin-2-one 
• 112674-75-6 (S)-3-Methyl-2-[(3R,4S)-2-oxo-3-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-4-phenyl-azetidin-1-yl]-butyric acid methyl ester 
• 99333-60-5 (4R,3'S,4'S)-3-<2'-oxo-4'-(2-phenylethenyl)-1'-(phenylmethyl)-3'-azetidinyl>-4-phenyl-2-oxazolidinone 
• 99333-60-5 (4R,3'R,4'R)-3-<2'-oxo-4'-(2-phenylethenyl)-1'-(phenylmethyl)-3'-azetidinyl>-4-phenyl-2-oxazolidinone 
• 135415-83-7 methyl (4'R,7S,8S)-9-oxo-8-(2'-oxo-4'-phenyl-1',3'-oxazolidin-3'-yl)-1,2-diazabicyclo<5.2.0>nona-3,5-diene-2-carboxylate 
• 135360-88-2 methyl (4'R,7R,8R)-9-oxo-8-(2'-oxo-4'-phenyl-1',3'-oxazolidin-3'-yl)-1,2-diazabicyclo<5.2.0>nona-3,5-diene-2-carboxylate 
• 135415-84-8 tert-butyl (4'R,7S,8S)-9-oxo-8-(2'-oxo-4'-phenyl-1',3'-oxazolidin-3'-yl)-1,2-diazabicyclo<5.2.0>nona-3,5-diene-2-carboxylate 
• 135360-89-3 tert-butyl (4'R,7R,8R)-9-oxo-8-(2'-oxo-4'-phenyl-1',3'-oxazolidin-3'-yl)-1,2-diazabicyclo<5.2.0>nona-3,5-diene-2-carboxylate 
• 135415-82-6 benzyl (4'R,7S,8S)-5-methyl-9-oxo-8-(2'-oxo-4'-phenyl-1',3'-oxazolidin-3'-yl)-1,2-diazabicyclo<5.2.0>nona-3,5-diene-2-carboxylate 
• 135360-87-1 benzyl (4'R,7R,8R)-5-methyl-9-oxo-8-(2'-oxo-4'-phenyl-1',3'-oxazolidin-3'-yl)-1,2-diazabicyclo<5.2.0>nona-3,5-diene-2-carboxylate 
• 112674-76-7 (S)-4-Methylsulfanyl-2-[(3R,4S)-2-oxo-3-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-4-phenyl-azetidin-1-yl]-butyric acid methyl ester 
• 112711-65-6 (R)-3-Methyl-2-[(3R,4S)-2-oxo-3-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-4-phenyl-azetidin-1-yl]-butyric acid methyl ester 
• 144541-27-5 cis-(3R,4S)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one 
• 144541-26-4 cis-(3S,4R)-1-benzyl-3-<(R)-2-oxo-4-phenyloxazolidin-3-yl>-4-<(R)-3-<(tert-butoxycarbonyl)amino>-2,2-dimethyloxazolidin-4-yl>azetidin-2-one 

Relevant academic research and scientific papers

Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies

4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate (3b) is a potent, selective and systemically active inhibitor of intracellular NAAA activity, which produces profound anti-inflammatory effects in animal models. In the present work, we describe structure-activity relationship (SAR) studies on 3-aminoazetidin-2-one derivatives, which have led to the identification of 3b, and expand these studies to elucidate the principal structural and stereochemical features needed to achieve effective NAAA inhibition. Investigations on the influence of the substitution at the β-position of the 2-oxo-3-azetidinyl ring as well as on the effect of size and shape of the carbamic acid ester side chain led to the discovery of 3ak, a novel inhibitor of human NAAA that shows an improved physicochemical and drug-like profile relative to 3b. This favourable profile, along with the structural diversity of the carbamic acid chain of 3b, identify this compound as a promising new tool to investigate the potential of NAAA inhibitors as therapeutic agents for the treatment of pain and inflammation.

COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES

Compounds, and compositions, methods, and uses thereof, are described herein for treating neurodegenerative diseases and disorders. In particular, vasopressin receptor modulators, and compositions, methods and uses thereof, are described herein for treati

Asymmetric alkylations of a phenylalanylglycinate equivalent. Novel route to dipeptides bearing α-alkyl-α-amino acid residues

Asymmetric single and double alkylations of chiral β-lactam acetate 1, which is a chiral glycinate as well as a phenylalanylglycinate equivalent, are studied. First, the sequential asymmetric double alkylation of 1a is performed to give the corresponding