(5-Chloro-2,2-dioxo-2,3-dihydro-2λ⁶-benzo[c]isothiazol-1-yl)-(4-chloro-phenyl)-methanone

Base Information

• Chemical Name: (5-Chloro-2,2-dioxo-2,3-dihydro-2λ⁶-benzo[c]isothiazol-1-yl)-(4-chloro-phenyl)-methanone
• CAS No.: 111249-15-1
• Molecular Formula: C₁₄H₉Cl₂NO₃S
• Molecular Weight: 342.202

Synonyms:(5-Chloro-2,2-dioxo-2,3-dihydro-2λ⁶-benzo[c]isothiazol-1-yl)-(4-chloro-phenyl)-methanone

Chemical Property of (5-Chloro-2,2-dioxo-2,3-dihydro-2λ⁶-benzo[c]isothiazol-1-yl)-(4-chloro-phenyl)-methanone

Chemical Property:

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Technology Process of (5-Chloro-2,2-dioxo-2,3-dihydro-2λ⁶-benzo[c]isothiazol-1-yl)-(4-chloro-phenyl)-methanone

There total 4 articles about (5-Chloro-2,2-dioxo-2,3-dihydro-2λ⁶-benzo[c]isothiazol-1-yl)-(4-chloro-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-chloro-1,3-dihydro-2,1-benzisothiazole 2,2-dioxide (111310-59-9) + 4-chloro-benzoyl chloride (122-01-0) → (5-Chloro-2,2-dioxo-2,3-dihydro-2λ6-benzo[c]isothiazol-1-yl)-(4-chloro-phenyl)-methanone (111249-15-1)

Guidance literature:

With pyridine; at 0 ℃; for 3h;

Reference yield:

(2-chlorophenyl)-methanesulfonamide (89665-79-2) → (5-Chloro-2,2-dioxo-2,3-dihydro-2λ6-benzo[c]isothiazol-1-yl)-(4-chloro-phenyl)-methanone (111249-15-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / potassium carbonate, copper-bronze powder / various solvent(s) / 3 h / 180 °C

2: 63 percent / N-chlorosuccinimide / dimethylformamide / 0.5 h / 30 °C

3: 78 percent / pyridine / 3 h / 0 °C

With pyridine; N-chloro-succinimide; copper; potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

1,3-dihydro-2,1-benzisothiazole 2,2-dioxide (111248-89-6) → (5-Chloro-2,2-dioxo-2,3-dihydro-2λ6-benzo[c]isothiazol-1-yl)-(4-chloro-phenyl)-methanone (111249-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / N-chlorosuccinimide / dimethylformamide / 0.5 h / 30 °C

2: 78 percent / pyridine / 3 h / 0 °C

With pyridine; N-chloro-succinimide; In N,N-dimethyl-formamide;

upstream raw materials:

5-chloro-1,3-dihydro-2,1-benzisothiazole 2,2-dioxide

4-chloro-benzoyl chloride

(2-chlorophenyl)-methanesulfonamide

1,3-dihydro-2,1-benzisothiazole 2,2-dioxide

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