prop-2-en-1-yl (6S)-9-[ (1R)-1-(benzyloxy)ethyl]-12-[(benzyloxy)methyl]-2,2-dimethyl-4,7,10-trioxo-6-(propan-2-yl)-3-oxa-5,8,11-triazatridecan-13-oate

Base Information

Chemical Name:prop-2-en-1-yl (6S)-9-[ (1R)-1-(benzyloxy)ethyl]-12-[(benzyloxy)methyl]-2,2-dimethyl-4,7,10-trioxo-6-(propan-2-yl)-3-oxa-5,8,11-triazatridecan-13-oate
CAS No.:452956-86-4
Molecular Formula:C₃₄H₄₇N₃O₈
Molecular Weight:625.762
Hs Code.:

Synonyms:prop-2-en-1-yl (6S)-9-[ (1R)-1-(benzyloxy)ethyl]-12-[(benzyloxy)methyl]-2,2-dimethyl-4,7,10-trioxo-6-(propan-2-yl)-3-oxa-5,8,11-triazatridecan-13-oate

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Chemical Property of prop-2-en-1-yl (6S)-9-[ (1R)-1-(benzyloxy)ethyl]-12-[(benzyloxy)methyl]-2,2-dimethyl-4,7,10-trioxo-6-(propan-2-yl)-3-oxa-5,8,11-triazatridecan-13-oate

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Technology Process of prop-2-en-1-yl (6S)-9-[ (1R)-1-(benzyloxy)ethyl]-12-[(benzyloxy)methyl]-2,2-dimethyl-4,7,10-trioxo-6-(propan-2-yl)-3-oxa-5,8,11-triazatridecan-13-oate

There total 3 articles about prop-2-en-1-yl (6S)-9-[ (1R)-1-(benzyloxy)ethyl]-12-[(benzyloxy)methyl]-2,2-dimethyl-4,7,10-trioxo-6-(propan-2-yl)-3-oxa-5,8,11-triazatridecan-13-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 13734-41-3
t-Boc-L-valine

: 1613724-98-3
C₂₉H₃₈N₂O₇

: 452956-86-4
prop-2-en-1-yl (6S)-9-[ (1R)-1-(benzyloxy)ethyl]-12-[(benzyloxy)methyl]-2,2-dimethyl-4,7,10-trioxo-6-(propan-2-yl)-3-oxa-5,8,11-triazatridecan-13-oate

Guidance literature:: C₂₉H₃₈N₂O₇; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

t-Boc-L-valine; With diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 4.15h; Inert atmosphere;
DOI:10.1002/hlca.201300255

Reference yield:

: 132090-11-0
N-Boc-O-Bn-L-Ser allyl ester

: 452956-86-4
prop-2-en-1-yl (6S)-9-[ (1R)-1-(benzyloxy)ethyl]-12-[(benzyloxy)methyl]-2,2-dimethyl-4,7,10-trioxo-6-(propan-2-yl)-3-oxa-5,8,11-triazatridecan-13-oate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 4.15 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 4.15 h / 0 - 20 °C / Inert atmosphere

With trifluoroacetic acid; In dichloromethane;
DOI:10.1002/hlca.201300255

Reference yield:

: 15260-10-3
N-Boc-O-benzyl-L-threonine

: 452956-86-4
prop-2-en-1-yl (6S)-9-[ (1R)-1-(benzyloxy)ethyl]-12-[(benzyloxy)methyl]-2,2-dimethyl-4,7,10-trioxo-6-(propan-2-yl)-3-oxa-5,8,11-triazatridecan-13-oate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 4.15 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 4.15 h / 0 - 20 °C / Inert atmosphere

With trifluoroacetic acid; In dichloromethane;
DOI:10.1002/hlca.201300255