(N-menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)-1-cyclohexenamine

Base Information

• Chemical Name: (N-menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)-1-cyclohexenamine
• CAS No.: 156876-10-7
• Molecular Formula: C₂₂H₃₈N₂O₂
• Molecular Weight: 362.556
• Mol file: 156876-10-7.mol

Synonyms:(N-menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)-1-cyclohexenamine

Chemical Property of (N-menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)-1-cyclohexenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (N-menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)-1-cyclohexenamine

There total 2 articles about (N-menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)-1-cyclohexenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

pyrrolidine (123-75-1) + 2-(N-menthyloxycarbonyl)-N-(methylamino)cyclohexanone → (N-menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)-1-cyclohexenamine (156876-10-7)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 48h; Heating;

DOI:10.1080/00397919408010153

Reference yield:

trans-2-(N-menthyloxycarbonyl)-N-(methylamino)cyclohexanol → (N-menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)-1-cyclohexenamine (156876-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / PCC / CH₂Cl₂ / 3 h / Ambient temperature

2: 97 percent / PTSA*H₂O / benzene / 48 h / Heating

With toluene-4-sulfonic acid; pyridinium chlorochromate; In dichloromethane; benzene;

DOI:10.1080/00397919408010153

Reference yield:

(N-menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)-1-cyclohexenamine (156876-10-7) → 1S,2S-trans-N-(menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)cyclohexylamine + 1R,2S-cis-N-(menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)cyclohexylamine + 1S,2R-cis-N-(menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)cyclohexylamine + 1R,2R-trans-N-(menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)cyclohexylamine

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 23 ℃; for 4h; under 2280 Torr; Product distribution; var. catalysts;

DOI:10.1080/00397919408010153

upstream raw materials:

pyrrolidine