6-acetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester)

Base Information

• Chemical Name: 6-acetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester)
• CAS No.: 1374218-55-9
• Molecular Formula: C₃₀H₂₇NO₁₇
• Molecular Weight: 673.541
• Mol file: 1374218-55-9.mol

Synonyms:6-acetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester)

Chemical Property of 6-acetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-acetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester)

There total 2 articles about 6-acetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.7%

5,6-Diacetoxy-7-hydroxyflavon-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsaeure-methylester) (74304-67-9) → 6-acetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) (1374218-55-9)

Guidance literature:

With nitric acid; acetic acid; at 50 ℃; for 4h;

DOI:10.1007/s11426-011-4361-4

Reference yield:

baicalin (21967-41-9,27462-75-5,31564-28-0) → 6-acetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) (1374218-55-9)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / methanol; N,N-dimethyl-formamide / 48 h / 0 - 40 °C / Inert atmosphere

2: sodium acetate / N,N-dimethyl-formamide / 48 h / 40 °C

3: nitric acid; acetic acid / 4 h / 50 °C

With thionyl chloride; nitric acid; sodium acetate; acetic acid; In methanol; N,N-dimethyl-formamide;

DOI:10.1007/s11426-011-4361-4

Reference yield: 90.1%

6-acetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) (1374218-55-9) → 6-acetoxy-7-hydroxyflavon-8-amino-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) (1374218-57-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; at 20 ℃; under 3750.38 Torr;

DOI:10.1007/s11426-011-4361-4

upstream raw materials:

5,6-Diacetoxy-7-hydroxyflavon-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsaeure-methylester)

baicalin

Downstream raw materials:

6-acetoxy-7-hydroxyflavon-8-amino-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester)

Refernces