3-bromo-4-(2-((trimethylsilyl)ethynyl)phenoxy)benzonitrile

Base Information

• Chemical Name: 3-bromo-4-(2-((trimethylsilyl)ethynyl)phenoxy)benzonitrile
• CAS No.: 1325219-95-1
• Molecular Formula: C₁₈H₁₆BrNOSi
• Molecular Weight: 370.321
• Mol file: 1325219-95-1.mol

Synonyms:3-bromo-4-(2-((trimethylsilyl)ethynyl)phenoxy)benzonitrile

Chemical Property of 3-bromo-4-(2-((trimethylsilyl)ethynyl)phenoxy)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-bromo-4-(2-((trimethylsilyl)ethynyl)phenoxy)benzonitrile

There total 5 articles about 3-bromo-4-(2-((trimethylsilyl)ethynyl)phenoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-bromo-4-(2-iodophenoxy)benzonitrile (1325219-94-0) + trimethylsilylacetylene (1066-54-2) → 3-bromo-4-(2-((trimethylsilyl)ethynyl)phenoxy)benzonitrile (1325219-95-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 17h; Inert atmosphere;

DOI:10.1002/anie.201209510

Reference yield: 90.0%

trimethyl(propargyl)silane (13361-64-3) + 3-bromo-4-(2-iodophenoxy)benzonitrile (1325219-94-0) → 3-bromo-4-(2-((trimethylsilyl)ethynyl)phenoxy)benzonitrile (1325219-95-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1002/chem.201003559

Reference yield:

3-bromo-4-fluorobenzonitrile (79630-23-2) → 3-bromo-4-(2-((trimethylsilyl)ethynyl)phenoxy)benzonitrile (1325219-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 23 h / 95 °C

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 17 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/anie.201209510

upstream raw materials:

trimethyl(propargyl)silane

3-bromo-4-(2-iodophenoxy)benzonitrile

2-Iodophenol

3-bromo-4-fluorobenzonitrile