N-cyclopropyl-3-nitropyridin-2-amine

Base Information

• Chemical Name: N-cyclopropyl-3-nitropyridin-2-amine
• CAS No.: 290313-20-1
• Molecular Formula: C₈H₉N₃O₂
• Molecular Weight: 179.178
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00369442
• Wikidata: Q82156518
• Mol file: 290313-20-1.mol

Synonyms:N-cyclopropyl-3-nitropyridin-2-amine;290313-20-1;N2-cyclopropyl-3-nitropyridin-2-amine;Cyclopropyl-(3-nitro-pyridin-2-yl)-amine;Maybridge1_006176;2-Pyridinamine, N-cyclopropyl-3-nitro-;Oprea1_502902;SCHEMBL929085;HMS559A16;DTXSID00369442;MFCD00174356;AKOS008923276;N-cyclopropyl-3-nitro-pyridin-2-amine;Cyclopropyl-(3-nitropyridin-2-yl)amine;AM100629;BS-22198;CS-0157014;FT-0629720;A819726

Chemical Property of N-cyclopropyl-3-nitropyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.000129mmHg at 25°C
• Melting Point: 61ºC
• Refractive Index: 1.701
• Boiling Point: 334.3 °C at 760 mmHg
• Flash Point: 156 °C
• PSA: 70.74000
• Density: 1.453g/cm3
• LogP: 2.16030
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 179.069476538
• Heavy Atom Count: 13
• Complexity: 200

Purity/Quality:

99%, ^*data from raw suppliers

N-Cyclopropyl-3-nitropyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1NC2=C(C=CC=N2)[N+](=O)[O-]

Technology Process of N-cyclopropyl-3-nitropyridin-2-amine

There total 2 articles about N-cyclopropyl-3-nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + Cyclopropylamine (765-30-0) → N-cyclopropyl-3-nitropyridin-2-amine (290313-20-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

→ N-cyclopropyl-3-nitropyridin-2-amine (290313-20-1)

Guidance literature:

Reference yield:

N-cyclopropyl-3-nitropyridin-2-amine (290313-20-1) → (S)-3-cyclopropyl-2-oxo-2,3-dihydro-imidazo[4,5-b]pyridine-1-carboxylic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol

2.1: tetrahydrofuran / 2.5 h / Heating / reflux

3.1: triethylamine / dichloromethane / 1 h / 20 °C

3.2: 18 h

With hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

2-Chloro-3-nitropyridine

Cyclopropylamine

Downstream raw materials:

N2-cyclopropylpyridine-2,3-diamine

C₉H₉N₃O

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