(2R,3R,6R)-2-Benzyloxymethyl-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran

Base Information

Chemical Name:(2R,3R,6R)-2-Benzyloxymethyl-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran
CAS No.:201233-10-5
Molecular Formula:C₂₄H₃₀O₄
Molecular Weight:382.5
Hs Code.:

Synonyms:(2R,3R,6R)-2-Benzyloxymethyl-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran

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Chemical Property of (2R,3R,6R)-2-Benzyloxymethyl-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran

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Technology Process of (2R,3R,6R)-2-Benzyloxymethyl-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran

There total 5 articles about (2R,3R,6R)-2-Benzyloxymethyl-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 100-44-7
benzyl chloride

: 201233-09-2
[(2R,3R,6R)-6-(4-tert-Butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-yl]-methanol

: 201233-10-5
(2R,3R,6R)-2-Benzyloxymethyl-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran

Guidance literature:: With sodium hydroxide; tetrabutyl ammonium fluoride; In toluene; at 60 ℃; for 24h;
DOI:10.1021/jo9714674

Reference yield:

: 201233-05-8
p-tert-Butylphenyl 6-O-(tert-butyldimethylsilyl)-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside

: 201233-10-5
(2R,3R,6R)-2-Benzyloxymethyl-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) ClCH₂COOH, PPh₃, DEAD, 2.) CH₃ONa / 1.) toluol, 0 deg C, 30 min; room temperature, 24 h, 2.) MeOH, 1 h

2: 90 percent / NaH / tetrahydrofuran / 24 h / 25 °C

3: 100 percent / Bu₄NF*3H₂O / tetrahydrofuran / 2 h / Ambient temperature

4: 56 percent / nBu₄NF*3H₂O, NaOH / toluene / 24 h / 60 °C

With sodium hydroxide; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; chloroacetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;
DOI:10.1021/jo9714674

Reference yield:

: 201233-08-1
tert-Butyl-[(2R,3R,6R)-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

: 201233-10-5
(2R,3R,6R)-2-Benzyloxymethyl-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Bu₄NF*3H₂O / tetrahydrofuran / 2 h / Ambient temperature

2: 56 percent / nBu₄NF*3H₂O, NaOH / toluene / 24 h / 60 °C

With sodium hydroxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; toluene;
DOI:10.1021/jo9714674